The tumor microenvironment (TME) is a complex and ever-changing “rogue organ”
composed of its own blood supply, lymphatic and nervous systems, stroma, immune cells …

The role of genetic and epigenetic factors in tumor initiation and progression is well
documented. Histone deacetylases (HDACs), histone methyl transferases (HMTs), and DNA …

Cancer stem cells (CSCs) are a subpopulation of cancer cells with functions similar to those
of normal stem cells. Although few in number, they are capable of self-renewal, unlimited …

Dysregulation of microRNAs (miRNAs) is involved in the initiation and progression of
several human cancers, including breast cancer (BC), as strong evidence has been found …

Compelling evidence have demonstrated that bulk tumors can arise from a unique subset of
cells commonly termed “cancer stem cells” that has been proposed to be a strong driving …

Morbidity and mortality associated with pediatric malignant primary brain tumors remain high
in the absence of effective therapies. Macrophage-mediated phagocytosis of tumor cells via …

Background Although both long and micro RNAs are emerging as important functional
components in colorectal cancer (CRC) progression and metastasis, the mechanism of their …

Head and neck squamous carcinoma (HNSCC) is the sixth most prevalent cancer and one
of the most aggressive malignancies worldwide. Despite continuous efforts to identify …

Advances in cancer research in the past have led to an evolving understanding of cancer
pathogenesis and the development of novel drugs that significantly improve patient …

Cervical cancer (CC) is the fourth most common type of gynecological malignancy affecting
females worldwide. Most CC cases are linked to infection with high-risk human …