Absence of a simple code: how transcription factors read the genome
Transcription factors (TFs) influence cell fate by interpreting the regulatory DNA within a
genome. TFs recognize DNA in a specific manner; the mechanisms underlying this …
genome. TFs recognize DNA in a specific manner; the mechanisms underlying this …
Plant SAM-domain proteins start to reveal their roles
Proteins often act in complexes assembled via protein–protein interaction domains. The
sterile alpha motif (SAM) domain is one of the most prominent interaction domains in …
sterile alpha motif (SAM) domain is one of the most prominent interaction domains in …
A SAM oligomerization domain shapes the genomic binding landscape of the LEAFY transcription factor
Deciphering the mechanisms directing transcription factors (TFs) to specific genome regions
is essential to understand and predict transcriptional regulation. TFs recognize short DNA …
is essential to understand and predict transcriptional regulation. TFs recognize short DNA …
Dynamic BTB-domain filaments promote clustering of ZBTB proteins
L Mance, N Bigot, EZ Sánchez, F Coste… - Molecular Cell, 2024 - cell.com
The formation of dynamic protein filaments contributes to various biological functions by
clustering individual molecules together and enhancing their binding to ligands. We report …
clustering individual molecules together and enhancing their binding to ligands. We report …
Interplay of dFOXO and Two ETS-Family Transcription Factors Determines Lifespan in Drosophila melanogaster
N Alic, ME Giannakou, I Papatheodorou… - PLoS …, 2014 - journals.plos.org
Forkhead box O (FoxO) transcription factors (TFs) are key drivers of complex transcriptional
programmes that determine animal lifespan. FoxOs regulate a number of other TFs, but how …
programmes that determine animal lifespan. FoxOs regulate a number of other TFs, but how …
Longevity is determined by ETS transcription factors in multiple tissues and diverse species
AJ Dobson, R Boulton-McDonald, L Houchou… - PLoS …, 2019 - journals.plos.org
Ageing populations pose one of the main public health crises of our time. Reprogramming
gene expression by altering the activities of sequence-specific transcription factors (TFs) can …
gene expression by altering the activities of sequence-specific transcription factors (TFs) can …
[HTML][HTML] Repressive gene regulation synchronizes development with cellular metabolism
Metabolic conditions affect the developmental tempo of animals. Developmental gene
regulatory networks (GRNs) must therefore synchronize their dynamics with a variable …
regulatory networks (GRNs) must therefore synchronize their dynamics with a variable …
Divergent transcriptional regulatory logic at the intersection of tissue growth and developmental patterning
The Yorkie/Yap transcriptional coactivator is a well-known regulator of cellular proliferation
in both invertebrates and mammals. As a coactivator, Yorkie (Yki) lacks a DNA binding …
in both invertebrates and mammals. As a coactivator, Yorkie (Yki) lacks a DNA binding …
Dynamics and heterogeneity of a fate determinant during transition towards cell differentiation
Yan is an ETS-domain transcription factor responsible for maintaining Drosophila eye cells
in a multipotent state. Yan is at the core of a regulatory network that determines the time and …
in a multipotent state. Yan is at the core of a regulatory network that determines the time and …
[HTML][HTML] A comparative study of Pointed and Yan expression reveals new complexity to the transcriptional networks downstream of receptor tyrosine kinase signaling
The biochemical regulatory network downstream of receptor tyrosine kinase (RTK) signaling
is controlled by two opposing ETS family members: the transcriptional activator Pointed (Pnt) …
is controlled by two opposing ETS family members: the transcriptional activator Pointed (Pnt) …