Lymphatic and interstitial flow in the tumour microenvironment: linking mechanobiology with immunity
Tumours often engage the lymphatic system in order to invade and metastasize. The tumour-
draining lymph node may be an immune-privileged site that protects the tumour from host …
draining lymph node may be an immune-privileged site that protects the tumour from host …
The evolving knowledge on T and NK cells in classic Hodgkin lymphoma: Insights into novel subsets populating the immune microenvironment
Simple Summary In classic Hodgkin lymphoma, T and NK cells constitute a significant
fraction of the reactive microenvironment established by malignant Hodgkin Reed …
fraction of the reactive microenvironment established by malignant Hodgkin Reed …
KLF4 is a tumor suppressor in B-cell non-Hodgkin lymphoma and in classic Hodgkin lymphoma
H Guan, L Xie, F Leithäuser… - Blood, The Journal …, 2010 - ashpublications.org
The transcription factor KLF4 may act both as an oncogene and a tumor suppressor in a
tissue-depending manner. In T-and pre-B-cell lymphoma, KLF4 was found to act as tumor …
tissue-depending manner. In T-and pre-B-cell lymphoma, KLF4 was found to act as tumor …
T lymphocyte recruitment into renal cell carcinoma tissue: a role for chemokine receptors CXCR3, CXCR6, CCR5, and CCR6
KA Oldham, G Parsonage, RI Bhatt, DMA Wallace… - European urology, 2012 - Elsevier
BACKGROUND: Evidence suggests that some patients with renal cell carcinoma (RCC)
respond to immunomodulatory therapies that activate T lymphocytes. A prerequisite for …
respond to immunomodulatory therapies that activate T lymphocytes. A prerequisite for …
Adoptive T-cell therapy improves treatment of canine non–Hodgkin lymphoma post chemotherapy
CM O'Connor, S Sheppard, CA Hartline, H Huls… - Scientific reports, 2012 - nature.com
Clinical observations reveal that an augmented pace of T-cell recovery after chemotherapy
correlates with improved tumor-free survival, suggesting the add-back of T cells after …
correlates with improved tumor-free survival, suggesting the add-back of T cells after …
[HTML][HTML] PDL1 shapes the classical Hodgkin lymphoma microenvironment without inducing T-cell exhaustion
JG Taylor, E Truelove, A Clear, M Calaminici… - …, 2023 - ncbi.nlm.nih.gov
Classical Hodgkin lymphoma (CHL) is unusually sensitive to PD1 inhibition and PDL1 is
highly expressed on CHL cells and in the tumor microenvironment. This could be interpreted …
highly expressed on CHL cells and in the tumor microenvironment. This could be interpreted …
[PDF][PDF] CCR7 in blood cancers–review of its pathophysiological roles and the potential as a therapeutic target
C Cuesta-Mateos, F Terrón, M Herling - Frontiers in Oncology, 2021 - frontiersin.org
According to the classical paradigm, CCR7 is a homing chemokine receptor that grants
normal lymphocytes access to secondary lymphoid tissues such as lymph nodes or spleen …
normal lymphocytes access to secondary lymphoid tissues such as lymph nodes or spleen …
The circuitry of the tumor microenvironment in adult and pediatric Hodgkin lymphoma: cellular composition, cytokine profile, EBV, and exosomes
Abstract Background: Classical Hodgkin lymphoma (cHL) is a unique lymphoid malignancy
with a tumor microenvironment (TME) consisting of a small number of neoplastic—Hodgkin …
with a tumor microenvironment (TME) consisting of a small number of neoplastic—Hodgkin …
Emergence and molecular mechanisms of SARS-CoV-2 and HIV to target host cells and potential therapeutics
The emergence of a new coronavirus, in around late December 2019 which had first been
reported in Wuhan, China has now developed into a massive threat to global public health …
reported in Wuhan, China has now developed into a massive threat to global public health …
Reed-Sternberg cell–derived lymphotoxin-α activates endothelial cells to enhance T-cell recruitment in classical Hodgkin lymphoma
CW Fhu, AM Graham, CT Yap… - Blood, The Journal …, 2014 - ashpublications.org
It is known that cells within the inflammatory background in classical Hodgkin lymphoma
(cHL) provide signals essential for the continual survival of the neoplastic Hodgkin and …
(cHL) provide signals essential for the continual survival of the neoplastic Hodgkin and …