Bioelectronic medicine: preclinical insights and clinical advances

VA Pavlov, KJ Tracey - Neuron, 2022 - cell.com
The nervous system maintains homeostasis and health. Homeostatic disruptions underlying
the pathobiology of many diseases can be controlled by bioelectronic devices targeting CNS …

Functional vagotopy in the cervical vagus nerve of the domestic pig: implications for the study of vagus nerve stimulation

ML Settell, NA Pelot, BE Knudsen… - Journal of neural …, 2020 - iopscience.iop.org
Objective. Given current clinical interest in vagus nerve stimulation (VNS), there are
surprisingly few studies characterizing the anatomy of the vagus nerve in large animal …

[HTML][HTML] Organ-and function-specific anatomical organization of vagal fibers supports fascicular vagus nerve stimulation

N Jayaprakash, W Song, V Toth, A Vardhan, T Levy… - Brain stimulation, 2023 - Elsevier
Vagal fibers travel inside fascicles and form branches to innervate organs and regulate
organ functions. Existing vagus nerve stimulation (VNS) therapies activate vagal fibers non …

[HTML][HTML] Quantitative estimation of nerve fiber engagement by vagus nerve stimulation using physiological markers

YC Chang, M Cracchiolo, U Ahmed, I Mughrabi… - Brain stimulation, 2020 - Elsevier
Background Cervical vagus nerve stimulation (VNS) is a rapidly emerging bioelectronic
treatment for brain, metabolic, cardiovascular and immune disorders. Its desired and off …

Different transcutaneous auricular vagus nerve stimulation parameters modulate the anti-inflammatory effects on lipopolysaccharide-induced acute inflammation in …

YY Go, WM Ju, CM Lee, SW Chae, JJ Song - Biomedicines, 2022 - mdpi.com
Vagus nerve stimulation (VNS) is considered a potential method for anti-inflammation due to
the involvement of the VN in the cholinergic anti-inflammatory pathway (CAP) formation of a …

[HTML][HTML] Non-invasive brain stimulation for post-COVID-19 conditions: A systematic review

A Markser, J Vöckel, A Schneider… - The American Journal of …, 2024 - Elsevier
Abstract Alongside the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
pandemic, the number of patients with persistent symptoms following acute infection with …

Transcutaneous auricular vagus nerve stimulation induces stabilizing modifications in large-scale functional brain networks: towards understanding the effects of …

R von Wrede, T Rings, S Schach, C Helmstaedter… - Scientific reports, 2021 - nature.com
Transcutaneous auricular vagus nerve stimulation (taVNS) is a novel non-invasive brain
stimulation technique considered as a potential supplementary treatment option for subjects …

Human intracranial recordings reveal distinct cortical activity patterns during invasive and non-invasive vagus nerve stimulation

WL Schuerman, KV Nourski, AE Rhone, MA Howard… - Scientific reports, 2021 - nature.com
Vagus nerve stimulation (VNS) is being used increasingly to treat a wide array of diseases
and disorders. This growth is driven in part by the putative ability to stimulate the nerve non …

Specific vagus nerve stimulation parameters alter serum cytokine levels in the absence of inflammation

T Tsaava, T Datta-Chaudhuri, ME Addorisio… - Bioelectronic …, 2020 - Springer
Background Electrical stimulation of peripheral nerves is a widely used technique to treat a
variety of conditions including chronic pain, motor impairment, headaches, and epilepsy …

Timing of vagus nerve stimulation during fear extinction determines efficacy in a rat model of PTSD

RR Souza, MB Powers, RL Rennaker, CK McIntyre… - Scientific Reports, 2022 - nature.com
Studies have indicated that vagus nerve stimulation (VNS) enhances extinction learning in
rodent models. Here, we investigated if pairing VNS with the conditioned stimulus is …