Transcription factors (TFs) are key regulators of intrinsic cellular processes, such as
differentiation and development, and of the cellular response to external perturbation …

The “epigenetics” concept was first described in 1942. Thus far, chemical modifications on
histones, DNA, and RNA have emerged as three important building blocks of epigenetic …

The identification of mechanisms to promote memory T (Tmem) cells has important
implications for vaccination and anti-cancer immunotherapy,,–. Using a CRISPR-based …

Abstract We recently introduced Cleavage Under Targets & Tagmentation (CUT&Tag), an
epigenomic profiling strategy in which antibodies are bound to chromatin proteins in situ in …

Epigenome reprogramming after fertilization enables transcriptionally quiescent maternal
and paternal chromatin to acquire a permissive state for subsequent zygotic genome …

Germline commitment following primordial germ cell (PGC) specification during early human
development establishes an epigenetic programme and competence for gametogenesis …

The mechanism controlling the dynamic targeting of SWI/SNF has long been postulated to
be coordinated by transcription factors (TFs), yet demonstrating a specific TF influence has …

O-GlcNAc is a dynamic post-translational modification (PTM) that regulates protein functions.
In studying the regulatory roles of O-GlcNAc, a major roadblock is the inability to change O …

Embryonic cells exhibit diverse metabolic states. Recent studies have demonstrated that
metabolic reprogramming drives changes in cell identity by affecting gene expression …

Polycomb repressive complexes 1 and 2 (PRC1/2) maintain transcriptional silencing of
developmental genes largely by catalyzing the formation of mono-ubiquitinated histone H2A …