Cells of multicellular organisms need to communicate with each other and have evolved
various mechanisms for this purpose, the most direct and quickest of which is through …

Gap junctions (GJ), specialised membrane structures that mediate cell-to-cell
communication in almost all animal tissues, are composed of intercellular channel-forming …

It has become increasingly clear that the accumulation of proteins in specific regions of the
plasma membrane can facilitate cellular communication. These regions, termed signaling …

Gap junctional channels are a class of membrane channels composed of transmembrane
channel-forming integral membrane proteins termed connexins, innexins or pannexins that …

Gap junction channels connect the cytoplasms of adjacent cells through the end-to-end
docking of single-membrane structures called connexons, formed by a ring of six connexin …

Intercellular channels formed by connexin proteins play a pivotal role in the direct movement
of ions and larger cytoplasmic solutes between vascular endothelial cells, between vascular …

To mediate cell-to-cell communication via gap junction channels (GJCs), connexins (Cx)
traffic as hexameric hemichannels to the plasma membrane, which dock end-to-end …

Nonsyndromic Hearing Loss and Deafness, DFNA3 – RETIRED CHAPTER, FOR HISTORICAL
REFERENCE ONLY - Abstract - Europe PMC Sign in | Create an account https://orcid.org …

Hemichannels are transmembrane channels composed of either a connexin or pannexin
hexamer. The docking of the extracellular domains of connexin hemichannels contributed by …

Homozygous or compound heterozygous mutations in the GJC2 gene, encoding the gap
junction protein connexin47 (Cx47), cause the autosomal recessive hypomyelinating …