Pathogenesis and therapeutic mechanisms in immune thrombocytopenia (ITP)
Immune thrombocytopenia (ITP) is a complex autoimmune disease characterized by low
platelet counts. The pathogenesis of ITP remains unclear although both antibody-mediated …
platelet counts. The pathogenesis of ITP remains unclear although both antibody-mediated …
Mouse and human FcR effector functions
P Bruhns, F Jönsson - Immunological reviews, 2015 - Wiley Online Library
Mouse and human FcRs have been a major focus of attention not only of the scientific
community, through the cloning and characterization of novel receptors, and of the medical …
community, through the cloning and characterization of novel receptors, and of the medical …
Proteomic and transcriptomic profiling of brainstem, cerebellum and olfactory tissues in early-and late-phase COVID-19
Neurological symptoms, including cognitive impairment and fatigue, can occur in both the
acute infection phase of coronavirus disease 2019 (COVID-19) and at later stages, yet the …
acute infection phase of coronavirus disease 2019 (COVID-19) and at later stages, yet the …
Intravenous immunoglobulin therapy: how does IgG modulate the immune system?
I Schwab, F Nimmerjahn - Nature Reviews Immunology, 2013 - nature.com
Intravenous immunoglobulin (IVIG) preparations comprise pooled IgG antibodies from the
serum of thousands of donors and were initially used as an IgG replacement therapy in …
serum of thousands of donors and were initially used as an IgG replacement therapy in …
Properties of mouse and human IgG receptors and their contribution to disease models
P Bruhns - Blood, The Journal of the American Society of …, 2012 - ashpublications.org
Impressive advances in defining the properties of receptors for the Fc portion of
immunoglobulins (FcR) have been made over the past several years. Ligand specificities …
immunoglobulins (FcR) have been made over the past several years. Ligand specificities …
IVIG-mediated effector functions in autoimmune and inflammatory diseases
Intravenous immunoglobulin (IVIG) is a pooled preparation of normal IgG obtained from
several thousand healthy donors. It is widely used in the immunotherapy of a large number …
several thousand healthy donors. It is widely used in the immunotherapy of a large number …
Fcγ receptors as regulators of immune responses
F Nimmerjahn, JV Ravetch - Nature Reviews Immunology, 2008 - nature.com
In addition to their role in binding antigen, antibodies can regulate immune responses
through interacting with Fc receptors (FcRs). In recent years, significant progress has been …
through interacting with Fc receptors (FcRs). In recent years, significant progress has been …
Recapitulation of IVIG anti-inflammatory activity with a recombinant IgG Fc
RM Anthony, F Nimmerjahn, DJ Ashline, VN Reinhold… - Science, 2008 - science.org
It is well established that high doses of monomeric immunoglobulin G (IgG) purified from
pooled human plasma [intravenous immunoglobulin (IVIG)] confer anti-inflammatory activity …
pooled human plasma [intravenous immunoglobulin (IVIG)] confer anti-inflammatory activity …
Regulatory T cells inhibit dendritic cells by lymphocyte activation gene-3 engagement of MHC class II
B Liang, C Workman, J Lee, C Chew… - The Journal of …, 2008 - journals.aai.org
Abstract Lymphocyte activation gene-3 (LAG-3) is a CD4-related transmembrane protein
expressed by regulatory T cells that binds MHC II on APCs. It is shown in this study that …
expressed by regulatory T cells that binds MHC II on APCs. It is shown in this study that …
Anti-inflammatory actions of intravenous immunoglobulin
F Nimmerjahn, JV Ravetch - Annu. Rev. Immunol., 2008 - annualreviews.org
The remarkable success story of the therapeutic application of pooled immunoglobulin G
(IgG) preparations from thousands of donors, the so-called intravenous IgG (IVIG) therapy, to …
(IgG) preparations from thousands of donors, the so-called intravenous IgG (IVIG) therapy, to …