Mechanical properties of whole-body soft human tissues: a review

G Singh, A Chanda - Biomedical Materials, 2021 - iopscience.iop.org
The mechanical properties of soft tissues play a key role in studying human injuries and their
mitigation strategies. While such properties are indispensable for computational modelling …

Allometric scaling of skin thickness, elasticity, viscoelasticity to mass for micro-medical device translation: from mice, rats, rabbits, pigs to humans

JCJ Wei, GA Edwards, DJ Martin, H Huang… - Scientific reports, 2017 - nature.com
Emerging micro-scale medical devices are showing promise, whether in delivering drugs or
extracting diagnostic biomarkers from skin. In progressing these devices through animal …

Characterizing and engineering biomimetic materials for viscoelastic mechanotransduction studies

L Cacopardo, N Guazzelli… - Tissue Engineering Part B …, 2022 - liebertpub.com
The mechanical behavior of soft tissue extracellular matrix is time dependent. Moreover, it
evolves over time due to physiological processes as well as aging and disease. Measuring …

A temperature-responsive intravenous needle that irreversibly softens on insertion

KC Agno, K Yang, SH Byun, S Oh, S Lee… - Nature Biomedical …, 2023 - nature.com
The high stiffness of intravenous needles can cause tissue injury and increase the risk of
transmission of blood-borne pathogens through accidental needlesticks. Here we describe …

Millifluidic culture improves human midbrain organoid vitality and differentiation

E Berger, C Magliaro, N Paczia, AS Monzel, P Antony… - Lab on a Chip, 2018 - pubs.rsc.org
Human midbrain-specific organoids (hMOs) serve as an experimental in vitro model for
studying the pathogenesis of Parkinson's disease (PD). In hMOs, neuroepithelial stem cells …

All-polysaccharide, self-healing injectable hydrogels based on chitosan and oxidized hydroxypropyl polysaccharides

J Chen, BLB Nichols, AM Norris, CE Frazier… - …, 2020 - ACS Publications
Polysaccharide-based hydrogels are attractive materials for biomedical applications for
reasons that include their polyfunctionality, generally benign nature, and biodegradability …

3D printing of self-healing personalized liver models for surgical training and preoperative planning

Y Lu, X Chen, F Han, Q Zhao, T Xie, J Wu… - Nature …, 2023 - nature.com
Abstract 3D printing can produce intuitive, precise, and personalized anatomical models,
providing invaluable support for precision medicine, particularly in areas like surgical …

Comprehensive experimental assessments of rheological models' performance in elastography of soft tissues

SS Poul, J Ormachea, RG Gary, KJ Parker - Acta biomaterialia, 2022 - Elsevier
Elastography researchers have utilized several rheological models to characterize soft
tissue viscoelasticity over the past thirty years. Due to the frequency-dependent behavior of …

Stiffness analysis of 3D spheroids using microtweezers

D Jaiswal, N Cowley, Z Bian, G Zheng, KP Claffey… - PloS one, 2017 - journals.plos.org
We describe a novel mechanical characterization method that has directly measured the
stiffness of cancer spheroids for the first time to our knowledge. Stiffness is known to be a …

A hyperelastic model to capture the mechanical behaviour and histological aspects of the soft tissues

KK Dwivedi, P Lakhani, S Kumar, N Kumar - Journal of the Mechanical …, 2022 - Elsevier
It is well established that the soft connective tissues show a nonlinear elastic response that
comes from their microstructural arrangement. Tissues' microstructure alters with various …