Ulcerative colitis and Crohn's disease are the principal forms of inflammatory bowel disease.
Both represent chronic inflammation of the gastrointestinal tract, which displays …

Brain–gut interactions affect psychological wellbeing and symptom reporting in functional
gastrointestinal disorders; the presence of anxiety or depression is associated with the …

Background There is a great unmet need for advanced therapies that provide rapid, robust,
and sustained disease control for patients with ulcerative colitis. We assessed the efficacy …

Background Individuals with inflammatory bowel disease (IBD) are at increased risk of
developing anxiety or depression (A&D). Crohn's disease (CD) and ulcerative colitis (UC) …

Gut–brain dysregulation has been recognized by the scientific community as being crucial to
the understanding of chronic gastrointestinal conditions, and this has translated into the …

Background Pain is a frequently reported symptom of inflammatory bowel disease (IBD)
experienced by patients in active disease and remission. Psychological factors play a …

Background Abdominal pain is frequently reported by people with inflammatory bowel
disease (IBD), including in remission. Pain is an under‐treated symptom. Aim To …

Summary Background Serotonin (5‐hydroxytryptamine, 5‐HT) is an important mediator of
every major gut‐related function. Recent investigations also suggest that 5‐HT can influence …

Background Inflammatory bowel diseases [IBD], which are associated with a high disease
burden, are also reported to be accompanied by a high prevalence of psychiatric disorders …

Background: Tricyclic antidepressants (TCAs) have efficacy in treating irritable bowel
syndrome (IBS). Some clinicians use TCAs to treat residual symptoms in inflammatory bowel …