Transfer RNA (tRNA) is structurally unique among nucleic acids in harboring an astonishing
diversity of post-transcriptionally modified nucleoside. Two of the most radically modified …

Pyrrolopyrimidine containing compounds, also known as 7-deazapurines, are a collection of
purine-based metabolites that have been isolated from a variety of biological sources and …

This volume is a timely and comprehensive description of the many facets of DNA and RNA
modification-editing processes and to some extent repair mechanisms. Each chapter offers …

Transfer RNA (tRNA) from all organisms on this planet contains modified nucleosides, which
are derivatives of the four major nucleosides. tRNA from Escherichia coli/Salmonella …

Information is still quite limited concerning the structural requirements in tRNA molecules for
their post-transcriptional maturation by base and ribose modification enzymes. To address …

Prokaryotic tRNA guanine transglycosylase (TGT) catalyzes replacement of guanine (G) by
7-aminomethyl-7-deazaguanine (PreQ1) at the wobble position of four specific tRNAs …

tRNA‐guanine transglycosylases (TGT) are enzymes involved in the modification of the
anticodon of tRNAs specific for Asn, Asp, His and Tyr, leading to the replacement of guanine …

We demonstrate the site-specific incorporation of nucleobase derivatives bearing
fluorophores or affinity labels into a short RNA stem loop recognition motif by exchange of a …

Aminoacyl–tRNA synthetases are modular enzymes composed of a central active site
domain to which additional functional domains were appended in the course of evolution …

In yeast, inosine is found at the first position of the anticodon (position 34) of seven different
isoacceptor tRNA species, while inEscherichia coliit is present only in tRNAArg. The …