Metastatic melanoma is challenging to manage. Although targeted-and immune therapies
have extended survival, most patients experience therapy resistance. The adaptability of …

Over the past decades, melanoma-related mortality has remained nearly stable. The main
reason is treatment failure of metastatic disease and the inherently linked knowledge gap …

Melanoma is the deadliest form of commonly encountered skin cancer because of its rapid
progression towards metastasis,. Although metabolic reprogramming is tightly associated …

Infiltration of Foxp3+ regulatory T (T reg) cells is considered to be a critical step during tumor
development and progression. T reg cells supposedly suppress locally an effective anti …

Exosomes play a crucial role in the crosstalk between cancer associated fibroblasts (CAFs)
and cancer cells, contributing to carcinogenesis and the tumour microenvironment. Recent …

Perturbations in microRNA (miRNA) expression profiles have been reported for cutaneous
malignant melanoma (CMM) predominantly when examined in cell lines. Despite the rapidly …

Melanoma is known as an exceptionally aggressive and treatment-resistant human cancer.
Although a great deal of progress has been made in the past decade, including the …

The extent and nature of epigenomic changes associated with melanoma progression is
poorly understood. Through systematic epigenomic profiling of 35 epigenetic modifications …

Tumor microenvironment, including extracellular matrix (ECM) and stromal cells, is a key
player during tumor development, from initiation, growth and progression to metastasis …

Background The tumor microenvironment consists of stromal cells, extracellular matrix, and
physicochemical properties (eg, oxygenation, acidification). An important element of the …