Heterogeneity in quorum sensing‐regulated bioluminescence of Vibrio harveyi

C Anetzberger, T Pirch, K Jung - Molecular microbiology, 2009 - Wiley Online Library
Quorum sensing (QS) refers to the ability of bacterial populations to read out the local
environment for cell density and to collectively activate gene expression. Vibrio harveyi, one …

Design, synthesis, and anti-RNA virus activity of 6′-fluorinated-aristeromycin analogues

J Yoon, G Kim, DB Jarhad, HR Kim… - Journal of medicinal …, 2019 - ACS Publications
The 6′-fluorinated aristeromycins were designed as dual-target antiviral compounds aimed
at inhibiting both the viral RNA-dependent RNA polymerase (RdRp) and the host cell S …

Mycolic acid cyclopropanation is essential for viability, drug resistance, and cell wall integrity of Mycobacterium tuberculosis

D Barkan, Z Liu, JC Sacchettini, MS Glickman - Chemistry & biology, 2009 - cell.com
Mycobacterium tuberculosis infection remains a major global health problem complicated by
escalating rates of antibiotic resistance. Despite the established role of mycolic acid …

Autoinducers Act as Biological Timers in Vibrio harveyi

C Anetzberger, M Reiger, A Fekete, U Schell… - PloS one, 2012 - journals.plos.org
Quorum sensing regulates cell density-dependent phenotypes and involves the synthesis,
excretion and detection of so-called autoinducers. Vibrio harveyi strain ATCC BAA-1116 …

Structure–Activity Relationships of Neplanocin A Analogues as S-Adenosylhomocysteine Hydrolase Inhibitors and Their Antiviral and Antitumor Activities

G Chandra, YW Moon, Y Lee, JY Jang… - Journal of Medicinal …, 2015 - ACS Publications
On the basis of the potent inhibitory activity of neplanocin A (1) against S-
adenosylhomocysteine (AdoHcy) hydrolase, we analyzed the comprehensive structure …

Crystal structures of Mycobacterium tuberculosis S‐adenosyl‐L‐homocysteine hydrolase in ternary complex with substrate and inhibitors

MCM Reddy, G Kuppan, ND Shetty, JL Owen… - Protein …, 2008 - Wiley Online Library
S‐adenosylhomocysteine hydrolase (SAHH) is a ubiquitous enzyme that plays a central role
in methylation‐based processes by maintaining the intracellular balance between S …

Regulation of homocysteine metabolism by Mycobacterium tuberculosis S-adenosylhomocysteine hydrolase

A Singhal, G Arora, A Sajid, A Maji, A Bhat, R Virmani… - Scientific reports, 2013 - nature.com
Mycobacterium tuberculosis modulates expression of various metabolism-related genes to
adapt in the adverse host environment. The gene coding for M. tuberculosis S …

Structure, function and substrate preferences of archaeal S-adenosyl-l-homocysteine hydrolases

LH Koeppl, D Popadić, R Saleem-Batcha… - Communications …, 2024 - nature.com
S-Adenosyl-l-homocysteine hydrolase (SAHH) reversibly cleaves S-adenosyl-l-
homocysteine, the product of S-adenosyl-l-methionine-dependent methylation reactions …

S‐Adenosyl‐l‐Methionine Salvage Impacts Psilocybin Formation in “Magic” Mushrooms

R Demmler, J Fricke, S Dörner, M Gressler… - …, 2020 - Wiley Online Library
Psychotropic Psilocybe mushrooms biosynthesize their principal natural product psilocybin
in five steps, among them a phosphotransfer and two methyltransfer reactions, which …

Colorimetric Assay for S-Adenosylhomocysteine Hydrolase Activity and Inhibition Using Fluorosurfactant-Capped Gold Nanoparticles

JH Lin, CW Chang, ZH Wu, WL Tseng - Analytical chemistry, 2010 - ACS Publications
This study reports a simple colorimetric method for the sensitive detection of S-
adenosylhomocysteine hydrolase (SAHH) activity and inhibition using fluorosurfactant …