Context-dependent control of alternative splicing by RNA-binding proteins
XD Fu, M Ares Jr - Nature Reviews Genetics, 2014 - nature.com
Sequence-specific RNA-binding proteins (RBPs) bind to pre-mRNA to control alternative
splicing, but it is not yet possible to read the'splicing code'that dictates splicing regulation on …
splicing, but it is not yet possible to read the'splicing code'that dictates splicing regulation on …
Regulation of alternative splicing through coupling with transcription and chromatin structure
Alternative precursor messenger RNA (pre-mRNA) splicing plays a pivotal role in the flow of
genetic information from DNA to proteins by expanding the coding capacity of genomes …
genetic information from DNA to proteins by expanding the coding capacity of genomes …
Evolutionary dynamics of gene and isoform regulation in Mammalian tissues
Most mammalian genes produce multiple distinct messenger RNAs through alternative
splicing, but the extent of splicing conservation is not clear. To assess tissue-specific …
splicing, but the extent of splicing conservation is not clear. To assess tissue-specific …
Analysis and design of RNA sequencing experiments for identifying isoform regulation
Y Katz, ET Wang, EM Airoldi, CB Burge - Nature methods, 2010 - nature.com
Through alternative splicing, most human genes express multiple isoforms that often differ in
function. To infer isoform regulation from high-throughput sequencing of cDNA fragments …
function. To infer isoform regulation from high-throughput sequencing of cDNA fragments …
Genome-scale deletion screening of human long non-coding RNAs using a paired-guide RNA CRISPR–Cas9 library
CRISPR–Cas9 screens have been widely adopted to analyze coding-gene functions, but
high-throughput screening of non-coding elements using this method is more challenging …
high-throughput screening of non-coding elements using this method is more challenging …
[HTML][HTML] Hexanucleotide repeats in ALS/FTD form length-dependent RNA foci, sequester RNA binding proteins, and are neurotoxic
Summary The GGGGCC (G4C2) intronic repeat expansion within C9ORF72 is the most
common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia …
common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia …
The C9ORF72 GGGGCC expansion forms RNA G-quadruplex inclusions and sequesters hnRNP H to disrupt splicing in ALS brains
An expanded GGGGCC hexanucleotide in C9ORF72 (C9) is the most frequent known cause
of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). It has been …
of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). It has been …
RNA G-quadruplexes: emerging mechanisms in disease
A Cammas, S Millevoi - Nucleic acids research, 2017 - academic.oup.com
Abstract RNA G-quadruplexes (G4s) are formed by G-rich RNA sequences in protein-coding
(mRNA) and non-coding (ncRNA) transcripts that fold into a four-stranded conformation …
(mRNA) and non-coding (ncRNA) transcripts that fold into a four-stranded conformation …
The role of hnRNPs in frontotemporal dementia and amyotrophic lateral sclerosis
Dysregulated RNA metabolism is emerging as a crucially important mechanism
underpinning the pathogenesis of frontotemporal dementia (FTD) and the clinically …
underpinning the pathogenesis of frontotemporal dementia (FTD) and the clinically …
RNA G-quadruplex secondary structure promotes alternative splicing via the RNA-binding protein hnRNPF
It is generally thought that splicing factors regulate alternative splicing through binding to
RNA consensus sequences. In addition to these linear motifs, RNA secondary structure is …
RNA consensus sequences. In addition to these linear motifs, RNA secondary structure is …