In diarthrodial joints, the articular cartilage, calcified cartilage, and subchondral cortical and
trabecular bone form a biocomposite—referred to as the osteochondral unit—that is …

Osteoarthritis (OA) is a chronic degenerative disease of diarthrodial joints most commonly
affecting people over the age of forty. The causes of OA are still unknown and there is much …

Although cartilage degradation is the characteristic feature of osteoarthritis (OA), it is now
recognized that the whole joint is involved in the progression of OA. In particular, the …

Osteoarthritis (OA) is a common debilitating joint disorder, affecting large sections of the
population with significant disability and impaired quality of life. During OA, functional units …

Osteoarthritis (OA) is a prevalent disease of most mammalian species and is a significant
cause of welfare and economic morbidity in affected individuals and populations. In vitro …

Human embryonic stem cells (hESCs) have the potential to offer a virtually unlimited source
of chondrogenic cells for use in cartilage repair and regeneration. We have recently shown …

Osteoarthritis (OA) is a chronic disease mainly characterized by degenerative changes in
cartilage, but other joint elements such as bone are also affected. To date, there are no …

The articular cartilage and the subchondral bone form a biocomposite that is uniquely
adapted to the transfer of loads across the diarthrodial joint. During the evolution of the …

There is now general agreement that osteoarthritis (OA) involves all structures in the affected
joint, culminating in the degradation of the articular cartilage. It is appropriate to focus …

Background: Microfracture is a proven technique to treat articular cartilage defects in the
knee. However, there is little evidence in the literature to confirm the ability of microfracture …