Reperfusion injury, the paradoxical tissue response that is manifested by blood flow-
deprived and oxygen-starved organs following the restoration of blood flow and tissue …

Coronary artery disease is a major underlying etiology for heart failure. The role of coronary
microvascular disease, and endothelial dysfunction, in the pathophysiology of heart failure is …

At high concentrations, free radicals and radical-derived, nonradical reactive species are
hazardous for living organisms and damage all major cellular constituents. At moderate …

NIH 3T3 fibroblasts stably transformed with a constitutively active isoform of p21Ras, H-
RasV12 (vH-Ras or EJ-Ras), produced large amounts of the reactive oxygen species …

There is substantial evidence that oxidative stress participates in the pathophysiology of
cardiovascular disease. Biochemical, molecular and pharmacological studies further …

The polyamines are small organic cations that are absolutely required for eukaryotic cell
growth. Although their growth requirements are well established, the molecular functions of …

Oxidative stress is an increase in the reduction potential or a large decrease in the reducing
capacity of the cellular redox couples. A particularly destructive aspect of oxidative stress is …

While timely reperfusion of acute ischemic myocardium is essential for myocardial salvage,
reperfusion results in a unique form of myocardial damage. Functional alterations occur …

Nitrite is one of the players in the broad nitrogen biogeochemical cycle. This nitrogen oxo-
anion is involved in key pathways crucial to life on Earth and to the planetary “recycling” of …

Therapeutic strategies against free radicals have mostly focused on the augmentation of
antioxidant defenses (eg, vitamins C and E). A novel approach is to prevent free radical …