The lysyl oxidase family comprises five members in mammals, lysyl oxidase (LOX) and four
lysyl oxidase like proteins (LOXL1-4). They are copper amine oxidases with a highly …

Copper is an essential micronutrient involved in fundamental life processes that are
conserved throughout all forms of life. The ability of copper to catalyze oxidation–reduction …

Copper homeostasis is tightly regulated in both prokaryotic and eukaryotic cells to ensure
sufficient amounts for cuproprotein biosynthesis, while limiting oxidative stress production …

As an essential nutrient, copper's redox properties are both beneficial and toxic to cells.
Therefore, leveraging the characteristics of copper-dependent diseases or using copper …

Copper is an essential element for most aerobic organisms, with an important function as a
structural and catalytic cofactor, and in consequence, it is implicated in several biological …

Copper is an essential trace metal required by organisms to perform a number of important
biological processes. Copper readily cycles between its reduced Cu (i) and oxidised Cu (ii) …

Metastasis is currently the leading cause of cancer related death and is the most feared and
difficult to treat outcome for cancer patients. This complex process is regulated by a plethora …

Doxorubicin is a widely used anticancer drug in clinical practice for the treatment of various
human tumors. However, its administration is associated with cardiotoxicity. Administration …

We now want to begin to develop a holistic view of cartilage as a tissue that has an
integrated set of homeostatic processes for maintaining itself. In the context of other tissues …

Background: Kidney fibrosis is the ultimate consequence of advanced stages of chronic
kidney disease (CKD); however, there are currently no reliable biomarkers or noninvasive …