Control of proper protein synthesis, function, and turnover is essential for the health of all
cells. In neurons these demands take on the additional importance of supporting and …

Glaucoma is one of the leading causes of bilateral blindness, affecting nearly 57 million
people worldwide. Glaucoma is characterized by a progressive loss of retinal ganglion cells …

Covalent modification of histones is important in regulating chromatin dynamics and
transcription,. One example of such modification is ubiquitination, which mainly occurs on …

Polycomb group proteins Ring1b and Bmi1 (B‐cell‐specific M oloney murine leukaemia
virus i ntegration site 1) are critical components of the chromatin modulating PRC1 complex …

Insulin is the primary hormone involved in glucose homeostasis, and impairment of insulin
action and/or secretion has a critical role in the pathogenesis of diabetes mellitus. Type-II …

Polycomb complexes mediate gene silencing, in part by modifying histones. Ring1B and
Bmi1 are RING finger proteins that are members of the Polycomb repressive complex 1 …

Ubiquitin (Ub) chain types govern distinct biological processes. K48-linked polyUb chains
target substrates for proteasomal degradation, but the mechanism of Ub chain synthesis …

Salmonella translocate a group of type III effectors into the host cells to induce entry,
promote survival and cause intestinal inflammation. Although the biochemical and cellular …

The ubiquitin/proteasome system has been proposed to play an important role in
Alzheimer's disease (AD) pathogenesis. However, the critical factor (s) modulating both …

Polycomb group (PcG) proteins form chromatin-associated, transcriptionally repressive
complexes, which are critically involved in the control of cell proliferation and differentiation …