Vertebrate sex determination: evolutionary plasticity of a fundamental switch

B Capel - Nature Reviews Genetics, 2017 - nature.com
The discovery of the Sry gene in 1990 triggered a revolution in our understanding of sex
determination. More recently, advances in non-model organisms have been fuelled by the …

[HTML][HTML] Sex determination: why so many ways of doing it?

D Bachtrog, JE Mank, CL Peichel, M Kirkpatrick… - PLoS …, 2014 - journals.plos.org
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Female-to-male sex reversal in mice caused by transgenic overexpression of Dmrt1

L Zhao, T Svingen, ET Ng, P Koopman - Development, 2015 - journals.biologists.com
Genes related to Dmrt1, which encodes a DNA-binding DM domain transcription factor, act
as triggers for primary sex determination in a broad range of metazoan species. However …

Cell fate commitment during mammalian sex determination

YT Lin, B Capel - Current opinion in genetics & development, 2015 - Elsevier
The gonads form bilaterally as bipotential organs that can develop as testes or ovaries. All
secondary sex characteristics that we associate with 'maleness' or 'femaleness' depend on …

Sex chromosome transformation and the origin of a male-specific X chromosome in the creeping vole

MB Couger, SW Roy, N Anderson, L Gozashti, S Pirro… - Science, 2021 - science.org
The mammalian sex chromosome system (XX female/XY male) is ancient and highly
conserved. The sex chromosome karyotype of the creeping vole (Microtus oregoni) …

Applying real-time quantitative PCR to diagnosis of freemartin in Holstein cattle by quantifying SRY gene: a comparison experiment

Q Qiu, T Shao, Y He, B Cao, H Su - PeerJ, 2018 - peerj.com
Background Freemartinism generally occurs in female offspring of dizygotic twins in a mixed-
sex pregnancy. Most bovine heterosexual twin females are freemartins. However, about …

Sex reversal in non-human placental mammals

P Parma, F Veyrunes, E Pailhoux - Sexual Development, 2016 - karger.com
Gonads are very peculiar organs given their bipotential competence. Indeed, early
differentiating genital ridges evolve into either of 2 very distinct organs: the testis or the …

[HTML][HTML] Specificity of Key Sex Determination Genes in a Mammal with Ovotestes: The European Mole Talpa europaea

A Bogdanov, M Sokolova, I Bakloushinskaya - Animals, 2024 - mdpi.com
Simple Summary Simple Summary: The genetics of sex determination in mammals has
been studied mainly in humans and mice. However, some animals develop in other ways …

Wnt signaling in testis development: Unnecessary or essential?

WL Dong, FQ Tan, WX Yang - Gene, 2015 - Elsevier
Testis development is a fundamental process in sexual development and reproduction. It is
under the regulation of multiple factors. Wnt signaling pathway is a classical pathway, which …

The Biology and Evolution of Fierce Females (Moles and Hyenas)

R Jiménez, M Burgos… - Annual Review of Animal …, 2023 - annualreviews.org
Talpid moles and spotted hyenas have become the paradigms of anatomical and behavioral
female masculinization. Females of many mole species develop ovotestes that produce …