Gene mutations are strongly associated with tumor progression and are well known in
cancer development. However, recently discovered epigenetic alterations have shown the …

DNA sequencing-based studies of neurodevelopmental disorders (NDDs) have identified a
wide range of genetic determinants. However, a comprehensive analysis of these data, in …

Epigenetic regulation of gene expression provides a finely tuned response capacity for cells
when undergoing environmental changes. However, in the context of human physiology or …

Recent genomic data points to a growing role for somatic mutations altering core histone
and linker histone-encoding genes in cancer. However, the prevalence and the clinical and …

The polygenic nature of neurological and psychiatric syndromes and the significant impact
of environmental factors on the underlying developmental, homeostatic, and neuroplastic …

Chromatin has an extremely flexible structure that allows the fine regulation of gene
expression. To orchestrate this process, small chemical modifications are dynamically …

Translation of maternal mRNAs is detected before transcription of zygotic genes and is
essential for mammalian embryo development. How certain maternal mRNAs are selected …

The responses of macrophages to lipopolysaccharide (LPS) might determine the direction of
clinical manifestations of sepsis, which is the immune response against severe infection …

Aging-related diseases such as cancer can be traced to the accumulation of molecular
disorder including increased DNA mutations and epigenetic drift. We provide a …

Drug addiction is a complex disease affected by numerous genetic and environmental
factors. Brain regions in reward pathway, neuronal adaptations, genetic and epigenetic …