Apico-basal polarity is typical of cells present in differentiated epithelium while front-rear
polarity develops in motile cells. In cancer development, the transition from epithelial to …

Cancer cells are strongly influenced by host cells within the tumour stroma and vice versa.
This leads to the development of a tumour microenvironment with distinct physical and …

In chemotaxing ameboid cells, a complex leading-edge signaling circuit forms on the
cytoplasmic leaflet of the plasma membrane and directs both actin and membrane …

Abstract Clear cell Renal Cell Carcinoma (ccRCC) is one of the most prevalent kidney
cancers, which is often asymptomatic and thus discovered at a metastatic state (mRCC) …

Neutrophils must navigate accurately towards pathogens in order to destroy invaders and
thus defend our bodies against infection. Here we show that hydrogen peroxide, a potent …

The leukocyte chemosensory pathway detects attractant gradients and directs cell migration
to sites of inflammation, infection, tissue damage, and carcinogenesis. Previous studies …

Calcium signaling has long been associated with key events of immunity, including
chemotaxis, phagocytosis, and activation. However, imaging and manipulation of calcium …

Background Though, first identified in the gastrointestinal tract, bitter taste receptors are now
believed to be ubiquitously expressed in several regions of the body, including the …

MARCKS (myristoylated alanine-rich C kinase substrate) is a prominent PKC substrate
expressed in all eukaryotic cells. It is known to bind to and cross-link actin filaments, to serve …

Cell migration is controlled by PI3Ks, which generate lipid messengers phosphatidylinositol-
3, 4, 5-trisphosphate and phosphatidylinositol-3, 4-bisphosphate [PI (3, 4) P2] and …