ClpP is a highly conserved serine protease that is a critical enzyme in maintaining protein
homeostasis and is an important drug target in pathogenic bacteria and various cancers. In …

Structural biology is currently undergoing a transformation into dynamic structural biology,
which reveals the dynamic structure of proteins during their functional activity to better …

The ability to reverse protein aggregation is vital to cells,. Hsp100 disaggregases such as
ClpB and Hsp104 are proposed to catalyse this reaction by translocating polypeptide loops …

The relevance of molecular mechanisms governing mitochondrial proteostasis to the
differentiation and function of hematopoietic and immune cells is largely elusive. Through …

Hsp104 is a hexameric AAA+ ATPase and protein disaggregase found in yeast, which
couples ATP hydrolysis to the dissolution of diverse polypeptides trapped in toxic …

We provide a stand-alone software, the BioAFMviewer, which transforms biomolecular
structures into the graphical representation corresponding to the outcome of atomic force …

Atomic force microscopy (AFM) can visualize the dynamics of single biomolecules under
near-physiological conditions. However, the scanning tip probes only the molecular surface …

In mammalian cells, nearly one-third of proteins are inserted into the endoplasmic reticulum
(ER), where they undergo oxidative folding and chaperoning assisted by approximately 20 …

Since the release of AlphaFold, researchers have actively refined its predictions and
attempted to integrate it into existing pipelines for determining protein structures. These …

High-speed atomic force microscopy (HS-AFM) allows direct observation of biological
molecules in dynamic action. However, HS-AFM has no atomic resolution. This article …