[HTML][HTML] Toxin-antitoxin systems as multilevel interaction systems

N Goeders, L Van Melderen - Toxins, 2014 - mdpi.com
Toxin-antitoxin (TA) systems are small genetic modules usually composed of a toxin and an
antitoxin counteracting the activity of the toxic protein. These systems are widely spread in …

Keeping the wolves at bay: antitoxins of prokaryotic type II toxin-antitoxin systems

WT Chan, M Espinosa, CC Yeo - Frontiers in molecular biosciences, 2016 - frontiersin.org
In their initial stages of discovery, prokaryotic toxin-antitoxin (TA) systems were confined to
bacterial plasmids where they function to mediate the maintenance and stability of usually …

Emerging roles of toxin-antitoxin modules in bacterial pathogenesis

B Kędzierska, F Hayes - Molecules, 2016 - mdpi.com
Toxin-antitoxin (TA) cassettes are encoded widely by bacteria. The modules typically
comprise a protein toxin and protein or RNA antitoxin that sequesters the toxin factor. Toxin …

Regulating toxin-antitoxin expression: controlled detonation of intracellular molecular timebombs

F Hayes, B Kędzierska - Toxins, 2014 - mdpi.com
Genes for toxin-antitoxin (TA) complexes are widely disseminated in bacteria, including in
pathogenic and antibiotic resistant species. The toxins are liberated from association with …

Cross-regulations between bacterial toxin–antitoxin systems: evidence of an interconnected regulatory network?

C Riffaud, ML Pinel-Marie, B Felden - Trends in microbiology, 2020 - cell.com
Toxin–antitoxin (TA) systems are ubiquitous among bacteria and include stable toxins
whose toxicity can be counteracted by RNA or protein antitoxins. They are involved in …

[HTML][HTML] Advances in the study of bacterial toxins, their roles and mechanisms in pathogenesis

C Ghazaei - The Malaysian Journal of Medical Sciences: MJMS, 2022 - ncbi.nlm.nih.gov
Pathogenic bacteria use various mechanisms to cause infections in the host. Bacterial
pathogens express a wide range of molecules. Bacterial toxins have a poisonous substance …

Bacterial toxin-antitoxin systems' cross-interactions—implications for practical use in medicine and biotechnology

L Boss, B Kędzierska - Toxins, 2023 - mdpi.com
Toxin-antitoxin (TA) systems are widely present in bacterial genomes. They consist of stable
toxins and unstable antitoxins that are classified into distinct groups based on their structure …

Auxiliary interfaces support the evolution of specific toxin–antitoxin pairing

GJ Grabe, RT Giorgio, AMJ Hall, RML Morgan… - Nature Chemical …, 2021 - nature.com
Toxin–antitoxin (TA) systems are a large family of genes implicated in the regulation of
bacterial growth and its arrest in response to attacks. These systems encode nonsecreted …

ParD antitoxin hotspot alters a disorder-to-order transition upon binding to its cognate ParE toxin, lessening its interaction affinity and increasing its protease …

KJ Snead, LL Moore, CR Bourne - Biochemistry, 2021 - ACS Publications
Type-II toxin–antitoxin (TA) systems are comprised of two tightly interacting proteins, and
operons encoding these systems have been identified throughout the genomes of bacteria …

Evaluating the potential for cross-interactions of antitoxins in type II TA systems

CH Tu, M Holt, S Ruan, C Bourne - Toxins, 2020 - mdpi.com
The diversity of Type-II toxin–antitoxin (TA) systems in bacterial genomes requires tightly
controlled interaction specificity to ensure protection of the cell, and potentially to limit cross …