Mitotic spindle orientation is essential for cell fate decisions, epithelial maintenance, and
tissue morphogenesis. In most animal cell types, the dynein motor complex is anchored at …

It is estimated that only 0.02% of disseminated tumour cells are able to seed overt
metastases. While this suggests the presence of environmental constraints to metastatic …

Tissue repair after spinal cord injury requires the mobilization of immune and glial cells to
form a protective barrier that seals the wound and facilitates debris clearing, inflammatory …

Cell interactions determine phenotypes, and intercellular communication is shaped by
cellular contexts such as disease state, organismal life stage, and tissue microenvironment …

Epithelia within tubular organs form and expand lumens. Failure of these processes can
result in serious developmental anomalies. Although tight junction assembly is crucial to …

Chronic kidney disease (CKD) represents the fastest growing pathology worldwide with a
prevalence of> 10% in many countries. In addition, kidney cancer represents 5% of all new …

Although modern clinical practices such as cesarean sections and perinatal antibiotics have
improved infant survival, treatment with broad-spectrum antibiotics alters intestinal …

During morphogenesis, molecular mechanisms that orchestrate biomechanical dynamics
across cells remain unclear. Here, we show a role of guidance receptor Plexin-B2 in …

Abstract Semaphorin 4C (Sema4C) expression in human breast cancers correlates with
poor disease outcome. Surprisingly, upon knock-down of Sema4C or its receptor PlexinB2 …

Oriented cell divisions are critical to establish and maintain cell fates and tissue
organization. Diverse extracellular and intracellular cues have been shown to provide …