Anticancer strategies by upregulating p53 through inhibition of its ubiquitination by MDM2

A Anifowose, AA Agbowuro, X Yang… - Medicinal Chemistry …, 2020 - Springer
The potentiation of p53 activity through inhibition of its negative regulator MDM2 is an
attractive strategy for anticancer therapy. Much progress has been made in the last decade …

[HTML][HTML] Apoptosis-inducing activity of synthetic hydrocarbon-stapled peptides in H358 cancer cells expressing KRASG12C

C Li, N Zhao, L An, Z Dai, X Chen, F Yang… - … Pharmaceutica Sinica B, 2021 - Elsevier
Lung cancers are the leading cause of cancer deaths worldwide and pose a grave threat to
human life and health. Non-small cell lung cancer (NSCLC) is the most frequent malignancy …