Cutaneous neurogenic inflammation (CNI) is inflammation that is induced (or enhanced) in
the skin by the release of neuropeptides from sensory nerve endings. Clinical manifestations …

Proteases are signaling molecules that specifically control cellular functions by cleaving
protease-activated receptors (PARs). The four known PARs are members of the large family …

Atopic dermatitis (AD) is a common, chronic-relapsing inflammatory skin disease with
significant disease burden. Genetic and environmental trigger factors contribute to AD …

Introduction Platelet-rich plasma (PRP) is nowadays widely applied in different clinical
scenarios, such as orthopedics, ophthalmology and healing therapies, as a growth factor …

The transient receptor potential vanilloid-1 (TRPV1) is a non-specific cation channel known
for its sensitivity to pungent vanilloid compound (ie capsaicin) and noxious stimuli, including …

The epidermis closely interacts with nerve endings, and both epidermis and nerves produce
substances for mutual sustenance. Neuropeptides, like substance P (SP) and calcitonin …

Itch is a topic to which everyone can relate. The physiological roles of itch are increasingly
understood and appreciated. The pathophysiological consequences of itch impact quality of …

Obesity increases the risk of adverse outcomes during acute critical illnesses such as burns,
severe trauma, and acute pancreatitis. Although individuals with more body fat and higher …

Platelets help prevent blood loss at sites of vascular injury. To do this, they adhere,
aggregate and form a procoagulant surface favorizing thrombin generation and fibrin …

Discovered in the 1990s, protease activated receptors 1 (PARs) are membrane-spanning
cell surface proteins that belong to the G protein coupled receptor (GPCR) family. A defining …