A reduction in particle size improves the solubility and bioavailability of pharmaceuticals.
The traditional methods utilized in this regard are associated with problems so the use of …

With an increasing interest in cocrystals due to various advantages, demand for large-scale
cocrystallization techniques is rising. Solution cocrystallization is a solvent-based approach …

The inability of many biopharmaceutical formulations to retain their structure and integrity
when in solution represents a major issue for their transport and storage, reducing their shelf …

Poor bioavailability and aqueous solubility represent a major constraint during the
development of new API molecules and can influence the impact of new medicines or halt …

Solid multicomponent systems (SMS) are gaining an increasingly important role in the
pharmaceutical industry, to improve the physicochemical properties of active pharmaceutical …

The most favored approach for drug administration is the oral route. Several anticancer
drugs come under this category and mostly lack solubility and oral bioavailability, which are …

Hesperetin (HST) is a bioflavonoid from citrus fruits and its clinical application is still
markedly limited by its poor water solubility (1.27 µg/mL). Herein, a complex nanoparticle …

Isoniazid is a drug commonly employed in the treatment of tuberculosis. One major barrier to
its widespread use is that it can undergo hydrolysis when stored inadequately, resulting in …

Pharmaceuticals in Biopharmaceutics Classification System (BCS) Class II (low solubility,
high permeability) are often modified to improve kinetic solubility. Co-crystallization and …

Bioactive compounds curcumin and resveratrol have been appointed to have potential for
prevention and treatment of several diseases, replacing synthetic compounds with limited …