Post-translational modifications of intermediate filament proteins: mechanisms and functions

NT Snider, MB Omary - Nature reviews Molecular cell biology, 2014 - nature.com
Intermediate filaments (IFs) are cytoskeletal and nucleoskeletal structures that provide
mechanical and stress-coping resilience to cells, contribute to subcellular and tissue-specific …

Cytoplasmic intermediate filaments in cell biology

S Etienne-Manneville - Annual review of cell and …, 2018 - annualreviews.org
Intermediate filaments (IFs) are one of the three major elements of the cytoskeleton. Their
stability, intrinsic mechanical properties, and cell type–specific expression patterns …

Epithelial-to-mesenchymal transition and invadopodia markers in breast cancer: Lumican a key regulator

K Karamanou, M Franchi, D Vynios… - Seminars in cancer biology, 2020 - Elsevier
A great hallmark of breast cancer is the absence or presence of estrogen receptors ERα and
ERβ, with a dominant role in cell proliferation, differentiation and cancer progression. Both …

Keratins in health and disease

DM Toivola, P Boor, C Alam, P Strnad - Current opinion in cell biology, 2015 - Elsevier
The cytoprotective keratins (K) compose the intermediate filaments of epithelial cells and
their inherited and spontaneous mutations give rise to keratinopathies. For example …

Intermediate filaments at the junction of mechanotransduction, migration, and development

R Sanghvi-Shah, GF Weber - Frontiers in cell and developmental …, 2017 - frontiersin.org
Mechanically induced signal transduction has an essential role in development. Cells
actively transduce and respond to mechanical signals and their internal architecture must …

The expanding significance of keratin intermediate filaments in normal and diseased epithelia

X Pan, RP Hobbs, PA Coulombe - Current opinion in cell biology, 2013 - Elsevier
Intermediate filaments are assembled from a diverse group of evolutionary conserved
proteins and are specified in a tissue-dependent, cell type-dependent, and context …

[HTML][HTML] Bidirectional interplay between vimentin intermediate filaments and contractile actin stress fibers

Y Jiu, J Lehtimäki, S Tojkander, F Cheng, H Jäälinoja… - Cell reports, 2015 - cell.com
The actin cytoskeleton and cytoplasmic intermediate filaments contribute to cell migration
and morphogenesis, but the interplay between these two central cytoskeletal elements has …

Networking galore: intermediate filaments and cell migration

BM Chung, JD Rotty, PA Coulombe - Current opinion in cell biology, 2013 - Elsevier
Intermediate filaments (IFs) are assembled from a diverse group of evolutionarily conserved
proteins and are specified in a tissue-dependent, cell type-dependent, and context …

Regulation of keratin network organization

F Loschke, K Seltmann, JE Bouameur… - Current opinion in cell …, 2015 - Elsevier
Keratins form the major intermediate filament cytoskeleton of epithelia and are assembled
from heterodimers of 28 type I and 26 type II keratins in cell-and differentiation-dependent …

Epithelial keratins: Biology and implications as diagnostic markers for liquid biopsies

S Werner, L Keller, K Pantel - Molecular aspects of medicine, 2020 - Elsevier
Keratins are essential elements of the cytoskeleton of normal and malignant epithelial cells.
Because carcinomas commonly maintain their specific keratin expression pattern during …