Natural recombination combines pieces of preexisting proteins to create new tertiary
structures and functions. We describe a computational protocol, called SEWING, which is …

The potential of engineered enzymes in industrial applications is often limited by their
expression levels, thermal stability, and catalytic diversity. De novo enzyme design faces …

The glycerophosphodiester phosphodiesterase (GDPD)‐like SMaseD/PLD domain family,
which includes phospholipase D (PLD) toxins in recluse spiders and actinobacteria, evolved …

Chameleon proteins are proteins which include sequences that can adopt α-helix–β-strand
(HE-chameleon) or α-helix–coil (HC-chameleon) or β-strand–coil (CE-chameleon) …

The wealth of available protein structural data provides unprecedented opportunity to study
and better understand the underlying principles of protein folding and protein structure …

Insertions and deletions in protein sequences, or indels, can disrupt structure and may result
in changes in protein folds during evolution or in association with alternative splicing. Pfl 6 …

Experimental conditions or the presence of interacting components can lead to variations in
the structural models of macromolecules. However, the role of these factors in …

Protein folding involves a stochastic search through the configurational energy landscape
towards the native structure. Although most proteins have evolved to fold efficiently into a …