Amide bonds are the most prevalent structures found in organic molecules and various
biomolecules such as peptides, proteins, DNA, and RNA. The unique feature of amide …

The metallobiochemistry of zinc enzymes Page 286 THE METALLOBIOCHEMISTRY OF ZINC
ENZYMES By BERT L. VALLEE and ALPHONSE GALDES, Center for Biochemical and …

Publisher Summary The interaction of proteins with small ligands embodies the fundamental
physicochemical principles that are operative in the physiological regulation of enzyme …

This book presents a detailed examination of the physical properties of proteins and their
associations with solvents, ligands, and each other. Incorporating observations from his …

The crystal structure of bovine carboxypeptidase A (Cox) has been refined at 1· 54 Å
resolution using the restrained least-squares algorithm of Hendrickson & Konnert (1981) …

Adenosylmethionine is a very important intermediate in both prokaryotes and eukaryotes
since it is involved in many biological reactions (1-8). Adenosylmethionine is the major …

The selective hydrolysis of the extremely stable phosphoester, peptide and ester bonds of
molecules by bio-inspired metal-based catalysts (metallohydrolases) is required in a wide …

C-Terminal residues play a pivotal role in dictating the structure and functions of proteins.
Herein, we report a mild, efficient, chemoselective, and site-selective chemical method that …

ABSTRACT A major goal in biomedical science is to move beyond static images of proteins
and other biological macromolecules to the internal dynamics underlying their function. This …

A high-resolution x-ray crystallographic investigation of the complex between
carboxypeptidase A (CPA; peptidyl-L-amino-acid hydrolase, EC 3.4. 17.1) and the slowly …