Hydrazone comprising compounds as promising anti-infective agents: Chemistry and structure-property relationship
Despite the adverse effects of microbial hazards on public health, major pharmaceutical
firms have left the field of anti-infective development and a dramatic reduction in the number …
firms have left the field of anti-infective development and a dramatic reduction in the number …
Recent advances in the synthesis of new benzothiazole based anti-tubercular compounds
This review highlights the recent synthetic developments of benzothiazole based anti-
tubercular compounds and their in vitro and in vivo activity. The inhibitory concentrations of …
tubercular compounds and their in vitro and in vivo activity. The inhibitory concentrations of …
Multi-step in silico discovery of natural drugs against COVID-19 targeting main protease
In continuation of our antecedent work against COVID-19, three natural compounds, namely,
Luteoside C (130), Kahalalide E (184), and Streptovaricin B (278) were determined as the …
Luteoside C (130), Kahalalide E (184), and Streptovaricin B (278) were determined as the …
New quinoline and isatin derivatives as apoptotic VEGFR-2 inhibitors: design, synthesis, anti-proliferative activity, docking, ADMET, toxicity, and MD simulation studies
EB Elkaeed, MS Taghour, HA Mahdy… - Journal of Enzyme …, 2022 - Taylor & Francis
New quinoline and isatin derivatives having the main characteristics of VEGFR-2 inhibitors
was synthesised. The antiproliferative effects of these compounds were estimated against …
was synthesised. The antiproliferative effects of these compounds were estimated against …
Design, synthesis, anti-proliferative evaluation, docking, and MD simulations studies of new thiazolidine-2, 4-diones targeting VEGFR-2 and apoptosis pathway
We report herein, the design and synthesis of thiazolidine-2, 4-diones derivatives as new
inhibitors for VEGFR-2. The designed members were assessed for their in vitro anticancer …
inhibitors for VEGFR-2. The designed members were assessed for their in vitro anticancer …
In Silico Exploration of Potential Natural Inhibitors against SARS-Cov-2 nsp10
In continuation of our previous effort, different in silico selection methods were applied to
310 naturally isolated metabolites that exhibited antiviral potentialities before. The applied …
310 naturally isolated metabolites that exhibited antiviral potentialities before. The applied …
In Silico Screening of Semi-Synthesized Compounds as Potential Inhibitors for SARS-CoV-2 Papain-like Protease: Pharmacophoric Features, Molecular Docking …
Papain-like protease is an essential enzyme in the proteolytic processing required for the
replication of SARS-CoV-2. Accordingly, such an enzyme is an important target for the …
replication of SARS-CoV-2. Accordingly, such an enzyme is an important target for the …
Discovery of new quinoline and isatine derivatives as potential VEGFR-2 inhibitors: Design, synthesis, antiproliferative, docking and MD simulation studies
A new set of quinoline and isatine derivatives were synthesized as antiangiogenic VEGFR-2
inhibitors. On a biological level, the in vitro ability of the obtained candidates to inhibit …
inhibitors. On a biological level, the in vitro ability of the obtained candidates to inhibit …
Novel indole-thiazolidinone conjugates: Design, synthesis and whole-cell phenotypic evaluation as a novel class of antimicrobial agents
In connection with our research program on the development of novel anti-tubercular
candidates, herein we report the design and synthesis of two different sets of indole …
candidates, herein we report the design and synthesis of two different sets of indole …
Development of Novel Isatin-Tethered Quinolines as Anti-Tubercular Agents against Multi and Extensively Drug-Resistant Mycobacterium tuberculosis
We describe the design and synthesis of two isatin-tethered quinolines series (Q6a–h and
Q8a–h), in connection with our research interest in developing novel isatin-bearing anti …
Q8a–h), in connection with our research interest in developing novel isatin-bearing anti …