The yeast two-hybrid system pioneered the field of in vivo protein-protein interaction
methods and undisputedly gave rise to a palette of ingenious techniques that are constantly …

Highlights•Protein–protein interactions (PPIs) have emerged as promising targets for drug
discovery.•PPI network (PPIN)-based analyses can reveal genotype–phenotype …

Background Co-expression correlations provide the ability to predict gene functionality
within specific biological contexts, such as different tissue and disease conditions. However …

Motivation: Recent advances in technology have dramatically increased the availability of
protein–protein interaction (PPI) data and stimulated the development of many methods for …

Background Identification of protein-protein interactions (PPIs) is essential for a better
understanding of biological processes, pathways and functions. However, experimental …

Protein phosphorylation plays a central role in creating a highly dynamic network of
interacting proteins that reads and responds to signals from growth factors in the cellular …

Protein–protein interactions (PPIs) play a crucial role in biology, and high-throughput
experiments have greatly increased the coverage of known interactions. Still, identification of …

For nearly 25 years, FlyBase (flybase. org) has provided a freely available online database
of biological information about Drosophila species, focusing on the model organism D …

Dietary restriction (DR), limiting nutrient intake from diet without causing malnutrition, delays
the aging process and extends lifespan in multiple organisms. The conserved life-extending …

The centromere is a chromatin region that is required for accurate inheritance of eukaryotic
chromosomes during cell divisions. Among the different centromere-associated proteins …