In recent years, the worldwide spread of the so-called high-risk clones of multidrug-resistant
or extensively drug-resistant (MDR/XDR) Pseudomonas aeruginosa has become a public …

The global emergence of multidrug-resistant Gram-negative bacteria is a growing threat to
antibiotic therapy. The chromosomally encoded drug efflux mechanisms that are ubiquitous …

The increasing prevalence of chronic and hospital-acquired infections produced by
multidrug-resistant (MDR) or extensively drug-resistant (XDR) Pseudomonas aeruginosa …

Biofilms are complex microbial associations anchored to abiotic or biotic surfaces,
embedded in extracellular matrix produced by the biofilms themselves where they interact …

Drug efflux pumps play a key role in drug resistance and also serve other functions in
bacteria. There has been a growing list of multidrug and drug-specific efflux pumps …

Gram-negative bacteria are responsible for a large proportion of antimicrobial-resistant
infections in humans and animals. Among this class of bacteria are also some of the most …

Mutation-dependent overproduction of intrinsic β-lactamase AmpC is considered the main
cause of resistance of clinical strains of Pseudomonas aeruginosa to antipseudomonal …

Pseudomonas aeruginosa, a Gram‐negative environmental species and an opportunistic
microorganism, establishes itself in vulnerable patients, such as those with cystic fibrosis or …

We compared the dynamics and mechanisms of resistance development to ceftazidime,
meropenem, ciprofloxacin, and ceftolozane-tazobactam in wild-type (PAO1) and mutator …

Pseudomonas aeruginosa is among the leading causes of severe nosocomial infections,
particularly affecting critically ill and immunocompromised patients. Here we review the …