Per gram of tissue, the kidneys are among our most highly perfused organs. Yet the renal
cortex and, in particular, the renal medulla are susceptible to hypoxia. In turn, hypoxia is a …

Our kidneys receive about one-fifth of the cardiac output at rest and have a low oxygen
extraction ratio, but may sustain, under some conditions, hypoxic injuries that might lead to …

Chronic kidney disease (CKD) is caused by hypoxia in the renal tissue, leading to
inflammation and increased migration of pathogenic cells. Studies showed that leukocytes …

To assess the physiological significance of arterial-to-venous (AV) oxygen shunting, we
generated a new pseudo-three-dimensional computational model of oxygen diffusion from …

Computational models have made a major contribution to the field of physiology. As the
complexity of our understanding of biological systems expands, the need for computational …

Concurrent three-dimensional imaging of the renal vascular and tubular systems on the
whole-kidney scale with capillary level resolution is labor-intensive and technically difficult …

We assessed the utility of synchrotron‐radiation micro‐computed tomography (micro‐CT) for
quantification of the radial geometry of the renal cortical vasculature. The kidneys of nine …

Oxygen is unlikely to be shunted along the preglomerular vasculature in sufficient quantities
to affect renal oxygenation. There may be substantial shunting at the level of the …

Most of the implementations of X-ray speckle-based phase tomography reported in the
literature to date are proof-of-principle demonstrations and mostly performed on samples of …

The kidney is the organ responsible for blood filtration and is supplied with blood
independently of its oxygen demand. This project was embedded in an overarching …