Staphylococcal biofilm development: structure, regulation, and treatment strategies

K Schilcher, AR Horswill - Microbiology and Molecular Biology …, 2020 - Am Soc Microbiol
In many natural and clinical settings, bacteria are associated with some type of biotic or
abiotic surface that enables them to form biofilms, a multicellular lifestyle with bacteria …

Synthetic glycans to improve current glycoconjugate vaccines and fight antimicrobial resistance

L Del Bino, KE Østerlid, DY Wu, F Nonne… - Chemical …, 2022 - ACS Publications
Antimicrobial resistance (AMR) is emerging as the next potential pandemic. Different
microorganisms, including the bacteria Acinetobacter baumannii, Clostridioides difficile …

Bacterial extracellular polysaccharides in biofilm formation and function

DH Limoli, CJ Jones, DJ Wozniak - Microbial Biofilms, 2015 - Wiley Online Library
The ability to construct and maintain a structured multicellular bacterial community depends
critically on the production of extracellular matrix components (1, 2). While the biofilm matrix …

[HTML][HTML] Polysaccharide intercellular adhesin in biofilm: structural and regulatory aspects

CR Arciola, D Campoccia, S Ravaioli… - Frontiers in cellular and …, 2015 - frontiersin.org
Staphylococcus aureus and Staphylococcus epidermidis are the leading etiologic agents of
implant-related infections. Biofilm formation is the main pathogenetic mechanism leading to …

[HTML][HTML] The staphylococcal exopolysaccharide PIA–Biosynthesis and role in biofilm formation, colonization, and infection

HTT Nguyen, TH Nguyen, M Otto - Computational and Structural …, 2020 - Elsevier
Exopolysaccharide is a key part of the extracellular matrix that contributes to important
mechanisms of bacterial pathogenicity, most notably biofilm formation and immune evasion …

Staphylococcus aureus biofilms: Properties, regulation, and roles in human disease

NK Archer, MJ Mazaitis, JW Costerton, JG Leid… - Virulence, 2011 - Taylor & Francis
Increasing attention has been focused on understanding bacterial biofilms and this growth
modality's relation to human disease. In this review we explore the genetic regulation and …

The pgaABCD Locus of Escherichia coli Promotes the Synthesis of a Polysaccharide Adhesin Required for Biofilm Formation

X Wang, JF Preston III, T Romeo - Journal of bacteriology, 2004 - Am Soc Microbiol
Production of a polysaccharide matrix is a hallmark of bacterial biofilms, but the composition
of matrix polysaccharides and their functions are not widely understood. Previous studies of …

Differential Roles of Poly-N-Acetylglucosamine Surface Polysaccharide and Extracellular DNA in Staphylococcus aureus and Staphylococcus epidermidis Biofilms

EA Izano, MA Amarante, WB Kher… - Applied and …, 2008 - Am Soc Microbiol
Staphylococcus aureus and Staphylococcus epidermidis are major human pathogens of
increasing importance due to the dissemination of antibiotic-resistant strains. Evidence …

Quorum sensing and bacterial biofilms

JS Dickschat - Natural product reports, 2010 - pubs.rsc.org
Covering: up to 2009 This review describes the chemistry of the bacterial biofilms including
the chemistry of their constituents and signalling compounds that mediate or inhibit the …

Potential targets for next generation antimicrobial glycoconjugate vaccines

F Micoli, P Costantino, R Adamo - FEMS microbiology reviews, 2018 - academic.oup.com
Cell surface carbohydrates have been proven optimal targets for vaccine development.
Conjugation of polysaccharides to a carrier protein triggers a T-cell-dependent immune …