Membrane transporters can be major determinants of the pharmacokinetic, safety and
efficacy profiles of drugs. This presents several key questions for drug development …

Organic anion transporting polypeptide (OATP) family transporters accept a number of drugs
and are increasingly being recognized as important factors in governing drug and …

ATP binding cassette (ABC) drug transporters play an important role in cancer drug
resistance, protection against xenobiotics, and in general in the passage of drugs through …

Importance of the field: The use of traditional medicines of natural origin is being
encouraged for the treatment of chronic disorders, as synthetic drugs in such cases may …

It is generally thought that many drug molecules are transported across biological
membranes via passive diffusion at a rate related to their lipophilicity. However, the types of …

Predicting clinically significant drug interactions during drug development is a challenge for
the pharmaceutical industry and regulatory agencies. Since the publication of the US Food …

Xenobiotics have been defined as chemicals to which an organism is exposed that are
extrinsic to the normal metabolism of that organism. Without metabolism, many xenobiotics …

Organic cation transporter 1, OCT1 (SLC22A1), is the major hepatic uptake transporter for
metformin, the most prescribed antidiabetic drug. However, its endogenous role is poorly …

Rivaroxaban, an oral, direct factor Xa inhibitor, has a dual mode of elimination in humans,
with two-thirds metabolized by the liver and one-third renally excreted unchanged. P …

Quercetin is a dietary flavonoid with potential chemoprotective effects, but has low
bioavailability because of poor aqueous solubility and low intestinal absorption. A quercetin …