Exposure of cells to high voltage electric pulses increases transiently membrane
permeability through membrane electroporation. Electroporation can be reversible and is …

Interleukin-12 (IL-12) is a potent, pro-inflammatory type 1 cytokine that has long been
studied as a potential immunotherapy for cancer. Unfortunately, IL-12's remarkable …

This review summarizes the use of high-voltage electrical pulses (HVEPs) in clinical
oncology to treat solid tumors with irreversible electroporation (IRE) and …

The response rate of pancreatic cancer to chemotherapy or immunotherapy pancreatic
cancer is low. Although minimally invasive irreversible electroporation (IRE) ablation is a …

Immune checkpoint blockade targeting PD-1/PD-L1 has promising therapeutic efficacy in a
variety of tumors, but resistance during treatment is a major issue. In this review, we describe …

The intratumor microbiome imbalance in pancreatic cancer promotes a tolerogenic immune
response and triggers immunotherapy resistance. Here we show that Lactobacillus …

Simple Summary Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with a
dismal prognosis. While immunotherapy has been deemed a breakthrough treatment for …

Harnessing the immune system to treat cancer through inhibitors of CTLA4 and PD-L1 has
revolutionized the landscape of cancer. Rational combination strategies aim to enhance the …

Background Despite promising treatments for breast cancer, mortality rates remain high and
treatments for metastatic disease are limited. High-frequency irreversible electroporation (H …

Irreversible electroporation (IRE) has established a clinical niche as an alternative to thermal
ablation for the eradication of unresectable tumors, particularly those near critical vascular …