The past 20 years have seen dramatic changes in the delivery of radiation therapy, but the
impact of radiobiology on the clinic has been far less substantial. A major consideration in …

Histone deacetylases (HDACs) are enzymes involved in the remodelling of chromatin, and
have a key role in the epigenetic regulation of gene expression. In addition, the activity of …

Cyclin D1 is an important regulator of cell cycle progression and can function as a
transcriptionl co-regulator. The overexpression of cyclin D1 has been linked to the …

Glioblastoma, a rare, and highly lethal form of brain cancer, poses significant challenges in
terms of therapeutic resistance, and poor survival rates for both adult and paediatric patients …

Histone deacetylases (HDACs) can regulate expression of tumor suppressor genes and
activities of transcriptional factors involved in both cancer initiation and progression through …

Purpose Valproic acid (VPA) is an antiepileptic agent with histone deacetylase inhibitor
(HDACi) activity shown to sensitize glioblastoma (GBM) cells to radiation in preclinical …

Histone deacetylases (HDACs) regulate the acetylation of a variety of histone and
nonhistone proteins, controlling the transcription and regulation of genes involved in cell …

Seizures are a well-recognized symptom of primary brain tumors, and anticonvulsant use is
common. This paper provides an overview of epilepsy and the use of anticonvulsants in …

Cervical cancer remains one of the greatest killers of women worldwide. It is difficult to
foresee a dramatic increase in cure rate even with the most optimal combination of cytotoxic …

Patients with malignant brain tumors are prone to complications that negatively impact their
quality of life and sometimes their overall survival as well. Tumors may directly provoke …