Clerodane diterpenes: sources, structures, and biological activities

R Li, SL Morris-Natschke, KH Lee - Natural product reports, 2016 - pubs.rsc.org
Covering: 1990 to 2015 The clerodane diterpenoids are a widespread class of secondary
metabolites and have been found in several hundreds of plant species from various families …

Naturally occurring antinociceptive substances from plants

JB Calixto, A Beirith, J Ferreira… - … Journal Devoted to …, 2000 - Wiley Online Library
Despite the progress that has occurred in recent years in the development of therapy, there
is still a need for effective and potent analgesics, especially for the treatment of chronic pain …

Plantas medicinais: a necessidade de estudos multidisciplinares

MAM Maciel, AC Pinto, VF Veiga Jr, NF Grynberg… - Química nova, 2002 - SciELO Brasil
This paper presents a program emphasizing ethnopharmacological approaches that could
allow great success in the study of medicinal plants. The minimum ethnopharmacological …

Traditional uses, chemistry and pharmacology of Croton species (Euphorbiaceae)

A Salatino, MLF Salatino, G Negri - Journal of the Brazilian chemical …, 2007 - SciELO Brasil
Croton is a genus of Euphorbiaceae comprising around 1,300 species, widespread in
tropical regions of the Old and New Worlds. Several species have a long role in the …

Synthesis, anticonvulsant, and anti-inflammatory evaluation of some new benzotriazole and benzofuran-based heterocycles

KM Dawood, H Abdel-Gawad, EA Rageb… - Bioorganic & medicinal …, 2006 - Elsevier
Treatment of 2-bromoacetylbenzofuran with 1H-benzotriazole afforded 1-(benzofuran-2-yl)-2-
(benzotriazol-1-yl) ethanone which reacted with phenylisothiocyanate to give the …

Antileishmanial Activity of a Linalool-Rich Essential Oil from Croton cajucara

MSS Rosa, RR Mendonça-Filho… - Antimicrobial agents …, 2003 - Am Soc Microbiol
The in vitro leishmanicidal effects of a linalool-rich essential oil from the leaves of Croton
cajucara against Leishmania amazonensis were investigated. Morphological changes in L …

Ethnopharmacology, phytochemistry and pharmacology: a successful combination in the study of Croton cajucara

MAM Maciel, AC Pinto, AC Arruda… - Journal of …, 2000 - Elsevier
Phytochemical and pharmacological studies of Croton cajucara were oriented by traditional
medicine. The stem bark of the mature plant is a rich source of clerodane-type diterpenes …

Antinociceptive and Anti-Inflammatory Effects of the Saponin and Sapogenins Obtained from the Stem of Akebia quinata

J Choi, HJ Jung, KT Lee, HJ Park - Journal of medicinal food, 2005 - liebertpub.com
The stem of Akebia quinata Decasisne (Lardizabalaceae) has been used to treat urinary
tract inflammatory disease. It has been reported that saponins in medicinal plants may act as …

Genotoxicity evaluation of kaurenoic acid, a bioactive diterpenoid present in Copaiba oil

BC Cavalcanti, LV Costa-Lotufo, MO Moraes… - Food and chemical …, 2006 - Elsevier
Copaiba oil extracted from the Amazon traditional medicinal plant Copaifera langsdorffii is
rich in kaurenoic acid (ent-kaur-16-en-19-oic acid), a diterpene that has been shown to exert …

In vivo anti-inflammatory and antinociceptive effects of liriodendrin isolated from the stem bark of Acanthopanax senticosus

HJ Jung, HJ Park, RG Kim, KM Shin, J Ha… - Planta …, 2003 - thieme-connect.com
In the present study, liriodendrin isolated by activity-guided fractionation from the ethyl
acetate (EtOAc) extracts of the stem bark of Acanthopanax senticosus, was evaluated for anti …