Genome-wide association studies of cancer: current insights and future perspectives
Genome-wide association studies (GWAS) provide an agnostic approach for investigating
the genetic basis of complex diseases. In oncology, GWAS of nearly all common …
the genetic basis of complex diseases. In oncology, GWAS of nearly all common …
Validation of a DNA methylation microarray for 850,000 CpG sites of the human genome enriched in enhancer sequences
S Moran, C Arribas, M Esteller - Epigenomics, 2016 - Taylor & Francis
Aim: DNA methylation is the best known epigenetic mark. Cancer and other pathologies
show an altered DNA methylome. However, delivering complete DNA methylation maps is …
show an altered DNA methylome. However, delivering complete DNA methylation maps is …
[HTML][HTML] FXR regulates intestinal cancer stem cell proliferation
Increased levels of intestinal bile acids (BAs) are a risk factor for colorectal cancer (CRC).
Here, we show that the convergence of dietary factors (high-fat diet) and dysregulated WNT …
Here, we show that the convergence of dietary factors (high-fat diet) and dysregulated WNT …
[HTML][HTML] Genetic and epigenetic characteristics of inflammatory bowel Disease–Associated colorectal cancer
Background & Aims Inflammatory bowel disease (IBD) is a chronic, relapsing inflammatory
disorder associated with an elevated risk of colorectal cancer (CRC). IBD-associated CRC …
disorder associated with an elevated risk of colorectal cancer (CRC). IBD-associated CRC …
[HTML][HTML] The role of regulatory variation in complex traits and disease
FW Albert, L Kruglyak - Nature Reviews Genetics, 2015 - nature.com
We are in a phase of unprecedented progress in identifying genetic loci that cause variation
in traits ranging from growth and fitness in simple organisms to disease in humans …
in traits ranging from growth and fitness in simple organisms to disease in humans …
Role of non-coding sequence variants in cancer
Patients with cancer carry somatic sequence variants in their tumour in addition to the
germline variants in their inherited genome. Although variants in protein-coding regions …
germline variants in their inherited genome. Although variants in protein-coding regions …
Fast and efficient QTL mapper for thousands of molecular phenotypes
Motivation: In order to discover quantitative trait loci, multi-dimensional genomic datasets
combining DNA-seq and ChiP-/RNA-seq require methods that rapidly correlate tens of …
combining DNA-seq and ChiP-/RNA-seq require methods that rapidly correlate tens of …
[HTML][HTML] Apc restoration promotes cellular differentiation and reestablishes crypt homeostasis in colorectal cancer
LE Dow, KP O'Rourke, J Simon, DF Tschaharganeh… - Cell, 2015 - cell.com
The adenomatous polyposis coli (APC) tumor suppressor is mutated in the vast majority of
human colorectal cancers (CRC) and leads to deregulated Wnt signaling. To determine …
human colorectal cancers (CRC) and leads to deregulated Wnt signaling. To determine …
[HTML][HTML] An optimized shotgun strategy for the rapid generation of comprehensive human proteomes
This study investigates the challenge of comprehensively cataloging the complete human
proteome from a single-cell type using mass spectrometry (MS)-based shotgun proteomics …
proteome from a single-cell type using mass spectrometry (MS)-based shotgun proteomics …
[HTML][HTML] Epigenome-wide association study of COVID-19 severity with respiratory failure
MC de Moura, V Davalos, L Planas-Serra… - …, 2021 - thelancet.com
Background Patients infected with the severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), responsible for the coronavirus disease 2019 (COVID-19), exhibit a wide …
(SARS-CoV-2), responsible for the coronavirus disease 2019 (COVID-19), exhibit a wide …