Cilia play many essential roles in fluid transport and cellular locomotion, and as sensory
hubs for a variety of signal transduction pathways. Despite having a conserved basic …

The~ 100 MB genome of C. elegans codes for~ 20,000 protein-coding genes many of which
are required for the function of the nervous system, composed of 302 neurons in the adult …

The primary cilium is a microtubule-based organelle that senses extracellular signals as a
cellular antenna [1]. Primary cilia are found on many types of cells in our body and play …

G-protein-coupled receptors (GPCRs) are typically regarded as chemosensors that control
cellular states in response to soluble extracellular cues. However, the modality of stimuli …

The cilium evolved to provide the ancestral eukaryote with the ability to move and sense its
environment. Acquiring these functions required the compartmentalization of a dynein …

The Drosophila auditory organ shares equivalent transduction mechanisms with vertebrate
hair cells, and both are specified by atonal family genes. Using a whole-organ knockout …

The cilium is an essential organelle at the surface of mammalian cells whose dysfunction
causes a wide range of genetic diseases collectively called ciliopathies. The current rate at …

The multinational SYSCILIA consortium aims to gain a mechanistic understanding of the
cilium. We utilize multiple parallel high-throughput (HTP) initiatives to develop predictive …

Cilia are organelles specialized for movement and signaling. To infer when during evolution
signaling pathways became associated with cilia, we characterized the proteomes of cilia …

Echoing the repeated convergent evolution of flight and vision in large eukaryotes,
propulsive swimming motility has evolved independently in microbes in each of the three …