Synaptopathology involved in autism spectrum disorder

S Guang, N Pang, X Deng, L Yang, F He… - Frontiers in cellular …, 2018 - frontiersin.org
Autism spectrum disorder (ASD) encompasses a group of multifactorial neurodevelopmental
disorders characterized by impaired social communication, social interaction and repetitive …

CaM kinase: still inspiring at 40

KU Bayer, H Schulman - Neuron, 2019 - cell.com
Summary The Ca 2+/calmodulin (CaM)-dependent protein kinase II (CaMKII) was touted as
a memory molecule, even before its involvement in long-term potentiation (LTP) was shown …

Identification of an elaborate complex mediating postsynaptic inhibition

A Uezu, DJ Kanak, TWA Bradshaw, EJ Soderblom… - Science, 2016 - science.org
Inhibitory synapses dampen neuronal activity through postsynaptic hyperpolarization. The
composition of the inhibitory postsynapse and the mechanistic basis of its regulation …

The plasticitome of cortical interneurons

AR McFarlan, CYC Chou, A Watanabe… - Nature Reviews …, 2023 - nature.com
Hebb postulated that, to store information in the brain, assemblies of excitatory neurons
coding for a percept are bound together via associative long-term synaptic plasticity. In this …

Whole-neuron synaptic mapping reveals spatially precise excitatory/inhibitory balance limiting dendritic and somatic spiking

DM Iascone, Y Li, U Sümbül, M Doron, H Chen… - Neuron, 2020 - cell.com
The balance between excitatory and inhibitory (E and I) synapses is thought to be critical for
information processing in neural circuits. However, little is known about the spatial principles …

Interneuron-specific plasticity at parvalbumin and somatostatin inhibitory synapses onto CA1 pyramidal neurons shapes hippocampal output

M Udakis, V Pedrosa, SEL Chamberlain… - Nature …, 2020 - nature.com
The formation and maintenance of spatial representations within hippocampal cell
assemblies is strongly dictated by patterns of inhibition from diverse interneuron …

Preserving the balance: diverse forms of long-term GABAergic synaptic plasticity

CQ Chiu, A Barberis, MJ Higley - Nature Reviews Neuroscience, 2019 - nature.com
Cellular mechanisms that regulate the interplay of synaptic excitation and inhibition are
thought to be central to the functional stability of healthy neuronal circuits. A growing body of …

The space where aging acts: Focus on the GABA ergic synapse

A Rozycka, M Liguz‐Lecznar - Aging cell, 2017 - Wiley Online Library
As it was established that aging is not associated with massive neuronal loss, as was
believed in the mid‐20th Century, scientific interest has addressed the influence of aging on …

Super-resolving microscopy in neuroscience

C Werner, M Sauer, C Geis - Chemical Reviews, 2021 - ACS Publications
Fluorescence imaging techniques play a pivotal role in our understanding of the nervous
system. The emergence of various super-resolution microscopy methods and specialized …

Nanoscale subsynaptic domains underlie the organization of the inhibitory synapse

KC Crosby, SE Gookin, JD Garcia, KM Hahm… - Cell reports, 2019 - cell.com
Inhibitory synapses mediate the majority of synaptic inhibition in the brain, thereby
controlling neuronal excitability, firing, and plasticity. Although essential for neuronal …