Medulloblastoma accounts for nearly 10% of all childhood brain tumors. These tumors occur
exclusively in the posterior fossa and have the potential for leptomeningeal spread …

Critical discoveries over the past two decades have transformed our understanding of
medulloblastoma from a single entity into a clinically and biologically heterogeneous …

Background Disease relapse occurs in around 30% of children with medulloblastoma, and
is almost universally fatal. We aimed to establish whether the clinical and molecular …

Abstract The HIT-SIOP-PNET4 randomised trial for standard risk medulloblastoma
(MB)(2001–2006) included 338 patients and compared hyperfractionated and conventional …

Long-term complications such as radiation-induced second malignancies occur in a subset
of patients following radiation-therapy, particularly relevant in pediatric patients due to the …

Background: Approximately 30% of children with medulloblastoma (MB) experience
recurrence, which is usually incurable. This study compared the overall survival (OS) of …

Summary The European Association of Neuro-Oncology (EANO) and EUropean RAre
CANcer (EURACAN) guideline provides recommendations for the diagnosis, treatment, and …

Despite aggressive management consisting of surgery, radiation therapy (RT), and systemic
therapy given alone or in combination, a significant proportion of patients with brain tumors …

Opinion statement Medulloblastoma (MB) is a malignant embryonal tumor of the posterior
fossa and is the most common type of brain cancer in pediatric patients. In contrast, adult MB …

Simple Summary Medulloblastoma is the commonest malignant brain tumour of childhood.
Disease relapse following maximal multi-modal therapy including upfront craniospinal …