Annual Research Review: The power of predictability–patterns of signals in early life shape neurodevelopment and mental health trajectories
The global burden of early life adversity (ELA) is profound. The World Health Organization
has estimated that ELA accounts for almost 30% of all psychiatric cases. Yet, our ability to …
has estimated that ELA accounts for almost 30% of all psychiatric cases. Yet, our ability to …
Early life stress and altered social behaviors: a perspective across species
Childhood and adolescent affiliations guide how individuals engage in social relationships
throughout their lifetime and adverse experiences can promote biological alterations that …
throughout their lifetime and adverse experiences can promote biological alterations that …
[HTML][HTML] Central amygdala CRF+ neurons promote heightened threat reactivity following early life adversity in mice
C Demaestri, M Pisciotta, N Altunkeser, G Berry… - Nature …, 2024 - nature.com
Failure to appropriately predict and titrate reactivity to threat is a core feature of fear and
anxiety-related disorders and is common following early life adversity (ELA). A population of …
anxiety-related disorders and is common following early life adversity (ELA). A population of …
Early life stress lastingly alters the function and AMPA‐receptor composition of glutamatergic synapses in the hippocampus of male mice
N Brosens, C Simon, HW Kessels… - Journal of …, 2023 - Wiley Online Library
Early postnatal life is a sensitive period of development that shapes brain structure and
function later in life. Exposure to stress during this critical time window can alter brain …
function later in life. Exposure to stress during this critical time window can alter brain …
[HTML][HTML] Peripheral clock gene oscillations are perturbed in neonatal and adult rat offspring raised under adverse limited bedding conditions
CD Walker, TC Delorme, S Kiessling, H Long… - Scientific Reports, 2023 - nature.com
Abstract Circadian (24-h) rhythms in the suprachiasmatic nucleus (SCN) are established in
utero in rodents, but rhythmicity of peripheral circadian clocks appears later in postnatal …
utero in rodents, but rhythmicity of peripheral circadian clocks appears later in postnatal …
[HTML][HTML] Early life adversity reduces affiliative behavior with a stressed cagemate and leads to sex-specific alterations in corticosterone responses in adult mice
Experiencing early life adversity (ELA) alters stress physiology and increases the risk for
developing psychiatric disorders. The social environment can influence dynamics of stress …
developing psychiatric disorders. The social environment can influence dynamics of stress …
Chd8 haploinsufficiency impacts rearing experience in C57BL/6 mice
Mutations in CHD8 are one of the highest genetic risk factors for autism spectrum disorder.
Studies in mice that investigate underlying mechanisms have shown Chd8 haploinsufficient …
Studies in mice that investigate underlying mechanisms have shown Chd8 haploinsufficient …
[HTML][HTML] Unlocking the epigenome: Stress and exercise induced Bdnf regulation in the prefrontal cortex
TS Campbell, K Donoghue, TL Roth - Neurotoxicology and Teratology, 2024 - Elsevier
Aversive caregiving in early life is a risk factor for aberrant brain and behavioral
development. This outcome is related to epigenetic dysregulation of the brain-derived …
development. This outcome is related to epigenetic dysregulation of the brain-derived …
[HTML][HTML] Early life adversity reduces affiliative behavior towards a distressed cagemate and leads to sex-specific alterations in corticosterone responses
Experiencing early life adversity (ELA) alters stress physiology and increases the risk for
developing psychiatric disorders. The social environment can influence dynamics of stress …
developing psychiatric disorders. The social environment can influence dynamics of stress …
[HTML][HTML] The lateral habenula integrates age and experience to promote social transitions in developing rats
D Cobb-Lewis, A George, S Hu, K Packard, M Song… - bioRxiv, 2024 - ncbi.nlm.nih.gov
Social behavior deficits are an early-emerging marker of psychopathology and are linked
with early caregiving quality. However, the infant neural substrates linking early care to …
with early caregiving quality. However, the infant neural substrates linking early care to …