Abstract Treatment-resistant schizophrenia (TRS), the persistence of positive symptoms
despite≥ 2 trials of adequate dose and duration of antipsychotic medication with …

Cigarette smoking continues to adversely affect the health of individuals with schizophrenia.
Both smoking and heavy nicotine dependence, given the complex biological findings, might …

Abstract Background Catechol-O-methyltransferase (COMT) has been shown to influence
clinical pain, descending modulation, and exercise-induced symptom worsening. COMT …

Treatment-resistant schizophrenia (TRS) often results in severe disability and functional
impairment. Currently, the diagnosis of TRS is largely exclusionary and emphasizes the …

Negative symptoms of schizophrenia, including anhedonia, represent a heavy burden on
patients and their relatives. These symptoms are associated with cortical hypodopamynergia …

Treatment-resistant schizophrenia is a lack of adequate response to antipsychotic
medications resulting in incomplete functional and social recovery from the illness. Different …

Treatment-resistant schizophrenia (TRS) is often associated with severe burden of disease,
poor quality of life and functional impairment. Clozapine is the gold standard for the …

Antipsychotic drugs target primarily dopaminergic system which makes catechol-O-
methyltransferase (COMT) an interesting target in studies searching for treatment response …

Having reported associations between catechol-O-methyltransferase (COMT) genotypes at
SNPs rs4818 and rs4680 with levels of soluble COMT (S-COMT) in human dorsolateral …

The projection from dopaminergic neurons to gamma-aminobutyric acid (GABA)
interneurons in the prefrontal cortex is involved in the etiology of schizophrenia. The impact …