Cellular senescence represents a distinct cell fate characterized by replicative arrest in
response to a host of extrinsic and intrinsic stresses. Senescence facilitates programming …

Senescence is a multi‐functional cell fate, characterized by an irreversible cell‐cycle arrest
and a pro‐inflammatory phenotype, commonly known as the senescence‐associated …

Aging is a natural but relentless process of physiological decline, leading to physical frailty,
reduced ability to respond to physical stresses (resilience) and, ultimately, organismal death …

With the continuous improvement of human technology, the medical field has gradually
moved from molecular therapy to cellular therapy. As a safe and effective therapeutic tool …

Over the past decades, mesenchymal stem cell (MSC)-based therapy has been intensively
investigated and shown promising results in the treatment of various diseases due to their …

Mesenchymal stem cells (MSCs) are one of the few stem cell types used in clinical practice
as therapeutic agents for immunomodulation and ischemic tissue repair, due to their unique …

Chimeric antigen receptor (CAR) T cells provide new perspectives for treatment of
hematological malignancies. Manufacturing of these cellular products includes culture …

Mesenchymal stem/stromal cells (MSCs) are a reservoir for tissue homeostasis and repair
that age during organismal aging. Beside the fundamental in vivo role of MSCs, they have …

Mesenchymal stem cells (MSC) isolated from different tissue sources exhibit multiple
biological effects and have shown promising therapeutic effects in a broad range of …

Culture expansion of primary cells evokes highly reproducible DNA methylation (DNAm)
changes. We have identified CG dinucleotides (CpGs) that become continuously hyper-or …