[HTML][HTML] Non-redundant functions of EMT transcription factors

MP Stemmler, RL Eccles, S Brabletz, T Brabletz - Nature cell biology, 2019 - nature.com
Epithelial–mesenchymal transition (EMT) is a crucial embryonic programme that is executed
by various EMT transcription factors (EMT-TFs) and is aberrantly activated in cancer and …

Synonymous but not silent: the codon usage code for gene expression and protein folding

Y Liu, Q Yang, F Zhao - Annual review of biochemistry, 2021 - annualreviews.org
Codon usage bias, the preference for certain synonymous codons, is found in all genomes.
Although synonymous mutations were previously thought to be silent, a large body of …

Cancer plasticity: the role of mRNA translation

LJ Lee, D Papadopoli, M Jewer, S Del Rincon… - Trends in cancer, 2021 - cell.com
Tumor progression is associated with dedifferentiated histopathologies concomitant with
cancer cell survival within a changing, and often hostile, tumor microenvironment. These …

Non-coding RNAs and glioblastoma: Insight into their roles in metastasis

SM Mousavi, M Derakhshan, F Baharloii… - Molecular Therapy …, 2022 - cell.com
Glioma, also known as glioblastoma multiforme (GBM), is the most prevalent and most lethal
primary brain tumor in adults. Gliomas are highly invasive tumors with the highest death rate …

The crucial role of ZEB2: from development to epithelial‐to‐mesenchymal transition and cancer complexity

M Fardi, M Alivand, B Baradaran… - Journal of cellular …, 2019 - Wiley Online Library
Zinc finger E‐box binding homeobox 2 (ZEB2) is a DNA‐binding transcription factor, which
is mainly involved in epithelial‐to‐mesenchymal transition (EMT). EMT is a conserved …

ZEB1 and IL-6/11-STAT3 signalling cooperate to define invasive potential of pancreatic cancer cells via differential regulation of the expression of S100 proteins

Q Al-Ismaeel, CP Neal, H Al-Mahmoodi… - British Journal of …, 2019 - nature.com
Background S100 proteins have been implicated in various aspects of cancer, including
epithelial-mesenchymal transitions (EMT), invasion and metastasis, and also in …

Long non‐coding RNA ZEB2‐AS1 promotes the proliferation, metastasis and epithelial mesenchymal transition in triple‐negative breast cancer by epigenetically …

G Zhang, H Li, R Sun, P Li, Z Yang, Y Liu… - Journal of cellular …, 2019 - Wiley Online Library
The triple‐negative breast cancer is the most malignant type of breast cancer. Its
pathogenesis and prognosis remain poor despite the significant advances in breast cancer …

ZEB2, a master regulator of the epithelial–mesenchymal transition, mediates trophoblast differentiation

SC DaSilva-Arnold, CY Kuo, V Davra… - MHR: Basic science …, 2019 - academic.oup.com
STUDY QUESTION Does the upregulation of the zinc finger E-box binding homeobox 2
(ZEB2) transcription factor in human trophoblast cells lead to alterations in gene expression …

Role of the RNA-binding protein La in cancer pathobiology

G Sommer, T Heise - RNA biology, 2021 - Taylor & Francis
ABSTRACT RNA-binding proteins are important regulators of RNA metabolism and are of
critical importance in all steps of the gene expression cascade. The role of aberrantly …

Codon optimality in cancer

SL Gillen, JA Waldron, M Bushell - Oncogene, 2021 - nature.com
A key characteristic of cancer cells is their increased proliferative capacity, which requires
elevated levels of protein synthesis. The process of protein synthesis involves the translation …