The mycobacterial bacillus is encompassed by a remarkably elaborate cell wall structure.
The mycolyl-arabinogalactan-peptidoglycan (mAGP) complex is essential for the viability of …

Physiological processes are mainly controlled by intermolecular recognition mechanisms
involving protein–protein and protein–ligand (low molecular weight molecules) interactions …

The direct evaluation of dissociation constants (KD) from the variation of saturation transfer
difference (STD) NMR spectroscopy values with the receptor–ligand ratio is not feasible due …

Mycobacterium tuberculosis (M. tb) is responsible for more deaths globally than any other
pathogen. The only available vaccine, bacillus Calmette-Guérin (BCG), has variable efficacy …

Actinobacteria is a group of diverse bacteria. Most species in this class of bacteria are
filamentous aerobes found in soil, including the genus Streptomyces perhaps best known for …

Understanding the dynamics of protein–ligand interactions, which lie at the heart of host–
pathogen recognition, represents a crucial step to clarify the molecular determinants …

Conspectus The cell surface (or cell wall) of bacteria is coated with carbohydrate (or glycan)
structures that play a number of important roles. These include providing structural integrity …

Context: Factors in honey that improve wound healing are poorly understood, but are
thought to include lipopolysaccharide (LPS), apalbumin-1 and-2, and a 5.8 kDa component …

Glycans are ubiquitous in nature, decorating our cells and serving as the initial points of
contact with any visiting entities. These glycan interactions are fundamental to host …

While target-based drug design has proved successful in several therapeutic areas, this
approach has not yet provided compelling outcomes in the field of antibacterial agents. This …