Introduction Rotavirus is the primary cause of severe acute gastroenteritis among children
under the age of five globally, leading to 128,500 to 215,000 vaccine-preventable deaths …

Rotavirus is a leading cause of severe diarrheal disease in infants and young children
worldwide. Vaccination offers the best protection against this disease, and two rotavirus …

Background A low-level risk of intussusception following rotavirus vaccination has been
observed in some settings and may vary by vaccine type. We examined the association …

Rotavirus is a major cause of severe pediatric diarrhea worldwide. In 2006, 2 live, oral
rotavirus vaccines, Rotarix and RotaTeq, were licensed for use in infants and were rapidly …

Background There is limited comprehensive evaluation of the methodology and reporting
quality of observational studies of vaccine safety. Methods Databases including Medline …

Relative risk (RR) is a preferred measure for investigating associations in clinical and
epidemiological studies with dichotomous outcomes. However, if the outcome of interest is …

Although vaccines are one of the most rigorously tested biological products, the safety
concerns persist globally. The vaccine safety concerns linked to measles, pentavalent and …

Introduction Rotavirus-associated diarrheal diseases significantly burden healthcare
systems, particularly affecting infants under five years. Both Rotarix™(RV1) and …

Both developed and developing countries carry a large burden of pediatric intussusception.
Sentinel site surveillance-based studies have highlighted the difference in the regional …

The evaluation of safety is critical in all clinical trials. However, the quantitative analysis of
safety data in clinical trials poses statistical difficulties because of multiple potentially …