The biological impacts of CEBPD on urothelial carcinoma development and progression

TC Chan, YL Shiue, CF Li - Frontiers in Oncology, 2023 - frontiersin.org
Urothelial carcinoma (UC), which includes urinary bladder urothelial carcinoma (UBUC) and
upper tract urothelial carcinoma (UTUC), is one of the most common malignancies …

[HTML][HTML] The dual role of C/EBPδ in cancer

L Hartl, JW Duitman, MF Bijlsma, CA Spek - Critical Reviews in Oncology …, 2023 - Elsevier
Abstract CCAAT/Enhancer-Binding Protein delta (C/EBPδ) is a transcription factor involved
in differentiation and inflammation. While sparsely expressed in adult tissues, aberrant …

Angiogenesis driven by the CEBPD–hsa-miR-429–VEGFA signaling axis promotes urothelial carcinoma progression

TC Chan, CH Hsing, YL Shiue, SK Huang, KL Hsieh… - Cells, 2022 - mdpi.com
Background and Purpose: This research aimed to excavate the alternative mechanism of
CEBPD on tumor growth and explore the biological significance of the CEBPD/hsa-miR …

The Janus kinase 1 is critical for pancreatic cancer initiation and progression

H Shrestha, PD Rädler, R Dennaoui, MN Wicker… - Cell Reports, 2024 - cell.com
Summary Interleukin-6 (IL-6)-class inflammatory cytokines signal through the Janus tyrosine
kinase (JAK)/signal transducer and activator of transcription (STAT) pathway and promote …

Biological significance of MYC and CEBPD coamplification in urothelial carcinoma: Multilayered genomic, transcriptional and posttranscriptional positive feedback …

TC Chan, YT Chen, KT Tan, CL Wu… - Clinical and …, 2021 - Wiley Online Library
Background and purpose The aim of this study is to decipher the underlying mechanisms of
CCAAT/enhancer‐binding protein delta (CEBPD)‐enhanced glycolysis as well as the …

C/EBP-Family redundancy determines patient survival and lymph node involvement in PDAC

L Hartl, JJTH Roelofs, F Dijk, MF Bijlsma… - International journal of …, 2023 - mdpi.com
Pancreatic ductal adenocarcinoma (PDAC) is a dismal disease with a poor clinical
prognosis and unsatisfactory treatment options. We previously found that the transcription …

C/EBPδ Suppresses Motility-Associated Gene Signatures and Reduces PDAC Cell Migration

L Hartl, PAF Maarschalkerweerd, JM Butler, XD Manz… - Cells, 2022 - mdpi.com
Pancreatic Ductal Adenocarcinoma (PDAC) is among the most aggressive human cancers
and occurs globally at an increasing incidence. Metastases are the primary cause of cancer …

[HTML][HTML] Identification of C/EBPδ‐Modifying Compounds as Potential Anticancer Agents Using a High‐Throughput Drug Screen

L Hartl, JW Duitman, HL Aberson… - Journal of Cellular …, 2025 - pmc.ncbi.nlm.nih.gov
ABSTRACT CCAAT/enhancer‐binding protein delta (C/EBPδ) has been shown to promote
tumour growth, drug resistance and metastasis formation in some cancers, whereas we …

[HTML][HTML] Hypoxia Abrogates Tumor-Suppressive Activities of C/EBPδ in Pancreatic Cancer

L Hartl, MS Ten Brink, HL Aberson, J Koster… - International Journal of …, 2024 - mdpi.com
Pancreatic ductal adenocarcinoma (PDAC) is a dismal disease with a low 5-year survival
rate of only 13%. Despite intense research efforts, PDAC remains insufficiently understood …

Non-tumor CCAAT/Enhancer-binding protein delta potentiates tumor cell extravasation and pancreatic cancer metastasis formation

JW Duitman, L Hartl, JJTH Roelofs, MF Bijlsma… - Biomolecules, 2021 - mdpi.com
CCAAT/enhancer-binding protein delta (C/EBPδ) is a transcription factor involved in
apoptosis and proliferation, which is downregulated in pancreatic ductal adenocarcinoma …