In vitro culture of Digitalis L.(Foxglove) and the production of cardenolides: An up-to-date review

SK Verma, AK Das, GS Cingoz, E Gurel - Industrial Crops and Products, 2016 - Elsevier
Abstract Digitalis L.(Foxglove, Plantaginaceae) genus is a representative of several
medicinal ornamental plants that are widely used in the production of herbal medicines …

Quo vadis Cardiac Glycoside Research?

J Bejček, M Jurášek, V Spiwok, S Rimpelová - Toxins, 2021 - mdpi.com
Cardiac glycosides (CGs), toxins well-known for numerous human and cattle poisoning, are
natural compounds, the biosynthesis of which occurs in various plants and animals as a self …

RNAi-mediated gene knockdown of progesterone 5β-reductases in Digitalis lanata reduces 5β-cardenolide content

J Klein, E Horn, M Ernst, T Leykauf, T Leupold… - Plant Cell Reports, 2021 - Springer
Abstract Key message Studying RNAi-mediated DlP5βR1 and DlP5βR2 knockdown shoot
culture lines of Digitalis lanata, we here provide direct evidence for the participation of …

Efficient direct shoot organogenesis, genetic stability and secondary metabolite production of micropropagated Digitalis purpurea L.

N Pérez-Alonso, R Martín, A Capote, A Pérez… - Industrial Crops and …, 2018 - Elsevier
Cardiovascular and cancer diseases are the first causes of death in the world. Digitalis
purpurea L. is a medicinal plant that produces secondary metabolites, like digoxin and …

Plastidial expression of 3β-hydroxysteroid dehydrogenase and progesterone 5β-reductase genes confer enhanced salt tolerance in tobacco

M Sameeullah, M Yildirim, N Aslam… - International Journal of …, 2021 - mdpi.com
The short-chain dehydrogenase/reductase (SDR) gene family is widely distributed in all
kingdoms of life. The SDR genes, 3β-hydroxysteroid dehydrogenase (3β-HSD) and …

In vitro regeneration and cardenolide determination of an endemic foxglove, Digitalis cariensis (Aegean Foxglove)

A Mohammed, B Yücesan, Ö Demir-Ordu… - In Vitro Cellular & …, 2015 - Springer
The genus Digitalis L. is one of the most pharmacologically important plant genera because
many Digitalis species produce cardenolides, which are commonly used for cardiac …

Enhancement of cardenolide production in transgenic Digitalis purpurea L. by expressing a progesterone-5β-reductase from Arabidopsis thaliana L.

E Kairuz, N Pérez-Alonso, A Capote-Pérez… - Industrial Crops and …, 2020 - Elsevier
Metabolic engineering of Digitalis purpurea L. has emerged as a powerful biotechnological
tool to enhance in vitro cardenolide biosynthesis. Thereto, Agrobacterium tumefaciens …

[PDF][PDF] Organogénesis in vitro en el género Digitalis

R Martín, B Chong-Pérez, N Pérez-Alonso - Biotecnología vegetal, 2015 - biblat.unam.mx
El género Digitalis es de especial interés gracias a las propiedades terapéuticas de sus
metabolitos secundarios, conocidos genéricamente como cardenólidos. Estos son …

[图书][B] Plant biotechnology and medicinal plants: Periwinkle, milk thistle and foxglove

MR Rady - 2019 - books.google.com
Plant tissue culture and advanced biotechnologies have proven to be influential tools that
complement conventional breeding and accelerate development of many medicinal plants …

Shoot Organogenesis, Genetic Stability, and Secondary Metabolite Production of Micropropagated Digitalis purpurea

E Kairuz, N Pérez-Alonso, G Angenon… - Plant Cell and Tissue …, 2021 - Springer
Digitalis purpurea L. is a cardenolide-producing medicinal and ornamental plant.
Cardenolides, like digoxin, are commonly used to treat congestive heart failure, cardiac …